Effect of grapefruit juice on clarithromycin pharmacokinetics

被引：32

作者：

Cheng, KL

Nafziger, AN

Peloquin, CA

Amsden, GW

机构：

[1] Bassett Healthcare, Dept Pharm Serv, Clin Pharmacol Res Ctr, Cooperstown, NY 13326 USA

[2] Bassett Healthcare, Dept Med, Cooperstown, NY 13326 USA

[3] Natl Jewish Med & Res Ctr, Infect Dis Pharmacokinet Lab, Denver, CO USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 04期

关键词：

D O I：

10.1128/AAC.42.4.927

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 +/- 35 versus 148 +/- 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 +/- 38 min versus 173 +/- 85; P = 0.01) but did not affect other pharmacokinetic parameters.

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收藏

页码：927 / 929

页数：3

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