Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis

被引：63

作者：

Caridha, Diana ^{[1
]}

Vesely, Brian ^{[1
]}

van Bocxlaer, Katrien ^{[2
,8
]}

Arana, Byron ^{[3
]}

Mowbray, Charles E. ^{[3
]}

Rafati, Sima ^{[4
]}

Uliana, Silvia ^{[5
]}

Reguera, Rosa ^{[6
]}

Kreishman-Deitrick, Mara ^{[1
]}

Sciotti, Richard ^{[1
]}

Buffet, Pierre ^{[7
]}

Croft, Simon L. ^{[2
]}

机构：

[1] Walter Reed Army Inst Res, Silver Spring, MD USA

[2] London Sch Hyg & Trop Med, London, England

[3] Drugs Neglected Dis Initiat DNDi, Geneva, Switzerland

[4] Inst Pasteur Inst, Dept Immunotherapy & Leishmania Vaccine Res, Tehran, Iran

[5] Univ Sao Paulo, Biomed Sci Inst, Dept Parasitol, Sao Paulo, SP, Brazil

[6] Univ Leon, Dept Biomed Sci, Leon, Spain

[7] INTS, Lab Excellence GR Ex, UniteA Biol InteAgreAe Globule Rouge, Paris, France

[8] Univ York, York Biomed Res Inst, Dept Biol, York, N Yorkshire, England

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE | 2019年 / 11卷

基金：

英国惠康基金; 巴西圣保罗研究基金会;

关键词：

Cutaneous leishmaniasis; Drug discovery; Drug development; In vitro assays; In vivo models; Pharmacokinetics; Formulations; Immunomodulatory drugs; IN-VITRO; VIANNIA BRAZILIENSIS; FLUORESCENT PROTEIN; VISCERAL LEISHMANIASIS; MUCOSAL LEISHMANIASIS; MESOCRICETUS-AURATUS; TOPICAL TREATMENT; INTERFERON-GAMMA; NATURAL MODEL; SKIN;

D O I：

10.1016/j.ijpddr.2019.06.003

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for cutaneous leishmaniasis (CL). Here we review the need for new treatments for CL, describe in vitro and in vivo assays, models and approaches taken over the past decade to establish a pathway for the discovery, and pre-clinical development of new drugs for CL. These recent advances include novel mouse models of infection using bioluminescent Leishmania, the introduction of PK/PD approaches to skin infection, and defined pre-clinical candidate profiles.

引用

页码：106 / 117

页数：12

共 116 条

[1] What's behind a sand fly bite? The profound effect of sand fly saliva on host hemostasis, inflammation and immunity [J].