Regulation and role of organic anion-transporting polypeptides (OATPs) in drug delivery at the choroid plexus

被引：6
作者：
Zhang, Hao [1 ]
Song, Yu-Ning [1 ]
Liu, Wei-Guo [1 ,2 ]
Guo, Xiu-Li [1 ]
Yu, Lu-Gang [3 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, Jinan 250012, Peoples R China
[2] Qianfoshan Hosp, Dept Pharm, Jinan 250014, Peoples R China
[3] Univ Liverpool, Sch Clin Sci, Liverpool Ctr Glycobiol, Henry Wellcome Lab Mol & Cellular Gastroenterol, Liverpool L69 3BX, Merseyside, England
来源：
JOURNAL OF CLINICAL NEUROSCIENCE | 2010年 / 17卷 / 06期
关键词：
Choroid plexus; Organic anion-transporting polypeptides; Regulation; Substrates; Transport mechanism; BLOOD-BRAIN-BARRIER; P-GLYCOPROTEIN; RAT-LIVER; NUCLEAR RECEPTORS; CSF BARRIER; IN-VITRO; EXPRESSION; PROTEIN; IDENTIFICATION; GLUTATHIONE;
D O I：
10.1016/j.jocn.2009.11.001
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The organic anion-transporting polypeptides (rodents: Oatps; human: OATPs) belong to the growing family of organic anion/prostaglandin transporters and are important components of the active efflux transport system at the choroid plexus epithelial cells. OATPs facilitate the elimination of xenobiotics and endogenous waste from the cerebrospinal fluid and prevent waste accumulation in the central nervous system (CNS). This review summarizes the structures, regulations and roles of Oatps/OATPs at the choroid plexus in drug delivery to the CNS. (C) 2009 Elsevier Ltd. All rights reserved.
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收藏
页码：679 / 684
页数：6
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