Matrix Metalloproteinases and Platelet Function

被引:45
作者
Gresele, Paolo [1 ]
Falcinelli, Emanuela [1 ]
Sebastiano, Manuela [1 ]
Momi, Stefania [1 ]
机构
[1] Univ Perugia, Sect Internal & Cardiovasc Med, Perugia, Italy
来源
MATRIX METALLOPROTEINSES AND TISSUE REMODELING IN HEALTH AND DISEASE: CARDIOVASCULAR REMODELING | 2017年 / 147卷
关键词
PERIPHERAL ARTERIAL-DISEASE; TISSUE INHIBITORS; CORONARY-ARTERY; MESSENGER-RNA; CD40; LIGAND; THROMBUS FORMATION; PROSTATE-CANCER; UP-REGULATION; DIFFERENTIAL REGULATION; GROWTH-FACTOR;
D O I
10.1016/bs.pmbts.2017.01.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Platelets contain and release several matrix metalloproteinases (MMPs) and their tissue inhibitors of matrix metalloproteinases (TIMPs), including MMP-1, -2, -3, -9, and -14 and TIMP-1, -2, and -4. Although devoid of a nucleus, platelets also synthesize TIMP-2 upon activation. Platelet-released MMPs/TIMPs, as well as MMPs generated by other cells within the cardiovascular system, modulate platelet function in health and disease. In particular, a normal hemostatic platelet response to vessel wall injury may be transformed into pathologic thrombus formation by the release from platelets and/or by the local generation of some MMPs. Moreover, platelets may localize the production of leukocyte-derived MMPs to sites of vascular damage, contributing to atherosclerosis development and complications and to arterial aneurysm formation. Finally, the interaction between platelets and tumor cells is strongly influenced by MMPs/TIMPs. All these mechanisms are emerging as important in atherothrombosis, inflammatory disease, and cancer growth and dissemination. Increasing knowledge of these mechanisms may open the way to novel therapeutic approaches.
引用
收藏
页码:133 / 165
页数:33
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