Transforming Growth Factor-β and Tumor Necrosis Factor-α Reduce the Sensitivity of MiaPaCa2 Pancreatic Cancer Cells to Lysis by NK Cells

被引：2
|
作者：
Ostapchuk, E. O. [1 ]
Kali, A. [1 ]
Belyaev, N. N. [1 ]
机构：
[1] MA Aitkhodzhin Inst Mol Biol & Biochem, Lab Mol Immunol & Immunobiotechnol, Alma Ata, Kazakhstan
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 165卷 / 02期
关键词：
pancreatic adenocarcinoma cells; natural killer cells; cytotoxicity; transforming growth factor-beta; tumor necrosis factor-alpha; HLA-G EXPRESSION; TGF-BETA; RECEPTORS; CARCINOMA; LIGANDS; TIGIT;
D O I：
10.1007/s10517-018-4143-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the role of cytokines TGF-beta and TNF alpha in reduction of the cytolytic activity of NK cells towards tumor cells. Exogenous TGF-beta and TNF alpha reduced the sensitivity of MiaPaCa2 pancreatic adenocarcinoma cells to NK cytotoxicity, which was associated with reduction of ULBP-1 expression and increase of HLA-E, HLA-G, CD155, and CD112 expression on Mia-PaCa2 cells. Changes in the expression of ligands for NK receptors on tumor cells induced by TGF-beta and TNF alpha may contribute to reduction of cytotoxicity of tumor-associated NK cells and thus prevent an adequate antitumor immune response leading to the disease progress.
引用
收藏
页码：259 / 263
页数：5
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