Heartfelt crosstalk: desensitization of the GIRK current

被引：13

作者：

Jan, LY ^{[1
]}

Jan, YN

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Sch, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94143 USA

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 09期

关键词：

D O I：

10.1038/35023646

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acetylcholine calms the heartbeat by activating G(i)-coupled receptors and G-protein-activated inwardly rectifying potassium (GIRK) channels. It also dampens the GIRK current by reducing PIP2 through G(q)-coupled receptors, These two types of receptors seem to be engaged in an intriguingly specific form of crosstalk, which leads to desensitization of the GIRK current.

引用

页码：E165 / E167

页数：3

共 15 条

[11] RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents [J].

Saitoh, O ;

Kubo, Y ;

Odagiri, M ;

Ichikawa, M ;

Yamagata, K ;

Sekine, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (14) :9899-9904

[12] ATP-dependent desensitization of the muscarinic K+ channel in rat atrial cells [J].

Shui, Z ;

Boyett, MR ;

Zang, WJ .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 505 (01) :77-93

[13] THE ACTIVE-ROLE OF BETA-GAMMA IN SIGNAL-TRANSDUCTION [J].

STERNWEIS, PC .

CURRENT OPINION IN CELL BIOLOGY, 1994, 6 (02) :198-203

[14] OPPOSING MECHANISMS OF REGULATION OF A G-PROTEIN-COUPLED INWARD RECTIFIER K+ CHANNEL IN RAT-BRAIN NEURONS [J].

VELIMIROVIC, BM ;

KOYANO, K ;

NAKAJIMA, S ;

NAKAJIMA, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1590-1594

[15] Copurification of brain G-protein β5 with RGS6 and RGS7 [J].

Zhang, JH ;

Simonds, WF .

JOURNAL OF NEUROSCIENCE, 2000, 20 (03) :art. no.-RC59

← 1 2 →