Heartfelt crosstalk: desensitization of the GIRK current

被引：13

作者：

Jan, LY ^{[1
]}

Jan, YN

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Sch, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94143 USA

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 09期

关键词：

D O I：

10.1038/35023646

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acetylcholine calms the heartbeat by activating G(i)-coupled receptors and G-protein-activated inwardly rectifying potassium (GIRK) channels. It also dampens the GIRK current by reducing PIP2 through G(q)-coupled receptors, These two types of receptors seem to be engaged in an intriguingly specific form of crosstalk, which leads to desensitization of the GIRK current.

引用

页码：E165 / E167

页数：3

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