CYP2E1 Pst I/Rsa I polymorphism and colorectal cancer risk: A meta-analysis

被引：19

作者：

Zhou, Guo-Wu ^{[1
]}

Hu, Jia ^{[2
]}

Li, Qiang ^{[1
]}

机构：

[1] Second Mil Med Univ, Dept Resp, Changhai Hosp, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Dept Oncol, Changhai Hosp, Shanghai 200433, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 23期

关键词：

Cytochrome P450 2E1; Pst I /Rsa I polymorphism; Colorectal cancer; Cancer susceptibility; Meta-analysis; RED MEAT INTAKE; GENETIC POLYMORPHISMS; METABOLIZING ENZYMES; CYTOCHROME-P450; 2E1; SUSCEPTIBILITY; ASSOCIATION; CONSUMPTION; GENOTYPES; 1A1;

D O I：

10.3748/wjg.v16.i23.2949

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To clarify the association between CYP2E1 Pst I / Rsa I polymorphism and susceptibility to colorectal cancer. METHODS: A meta-analysis based on 10 eligible case-control studies involving 4979 cases and 6012 controls was carried out to summarize the data on the association between CYP2E1 Rsa I /Pst I polymorphism and colorectal cancer risk. RESULTS: In comparison of the homozygote c2c2 and c2 carriers (c1c2 + c2c2) and the homozygous wild-type genotype (c1c1), no association was found between CYP2E1 Rsa I /Pst I polymorphism and colorectal cancer risk [odds ratio (OR) = 1.24 (95% CI: 0.93-1.66) for c2c2; OR = 1.02 (95% CI: 0.88-1.19) for c2 carriers]. In stratified analysis, Caucasians with c2c2 homozygote appeared to have an increased risk of colorectal cancer (OR = 2.67, 95% CI: 1.03-6.89, P = 0.043), no significant associations were found in other groups. CONCLUSION: c2c2 homozygote of CYP2E1 Pst I I Rsa I polymorphism may be associated with the increased risk of colorectal cancer in Caucasians, which needs further investigations. (C) 2010 Baishideng. All rights reserved.

引用

页码：2949 / 2953

页数：5

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