Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages

被引：30
作者：
Dunn, KLR [1 ]
Farrant, JL [1 ]
Langford, PR [1 ]
Kroll, JS [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Paediat, Mol Infect Dis Grp, Fac Med, London W2 1PG, England
来源：
INFECTION AND IMMUNITY | 2003年 / 71卷 / 03期
关键词：
D O I：
10.1128/IAI.71.3.1604-1607.2003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages, with sodC mutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.
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页码：1604 / 1607
页数：4
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