Thyroid cancer and renal transplantation: a meta-analysis

被引:25
作者
Karamchandani, Dheeraj [1 ]
Arias-Amaya, Ramiro [3 ]
Donaldson, Nora [3 ]
Gilbert, Jackie [3 ]
Schulte, Klaus-Martin [1 ,2 ]
机构
[1] Kings Coll London, Kings Coll Hosp, NHS Fdn Trust, Dept Endocrine Surg, London SE5 9RS, England
[2] Kings Coll London, Biostat Unit, Inst Dent, London SE5 9RS, England
[3] Kings Coll Hosp London, Dept Endocrinol, London, England
关键词
RISK; DIALYSIS; RECIPIENTS; CARCINOMA; VIRUS;
D O I
10.1677/ERC-09-0191
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Kidney transplantation and the associated immune suppression are associated with a significantly increased risk of developing cancer during long-term follow-up. Thyroid cancer has been recognised as a potential post-transplant risk but has not yet been subject of a focused review. We therefore performed a meta-analysis on data of 50 861 patients with a total follow-up of 198 595 patient-years and identified a 6.9-fold higher standardised incidence ratio (95% confidence interval 5.6-8.7, P<0.001) of thyroid cancer post renal transplantation as compared with a non-transplant group. All such cancers were of papillary type as far as histopathology was known. The mean time to discovery was 6.0 years post transplantation. This puts thyroid cancer into the group of high cancer risk following solid organ transplantation which already includes cervical cancer, non-melanoma skin cancer, oral and lip cancer and haematological malignancies. It is unclear what causes the increased cancer incidence. Inclusion of thyroid ultrasound in long-term post-transplant evaluation may help to ensure timely recognition of this condition. Endocrine-Related Cancer (2010) 17 159-167
引用
收藏
页码:159 / 167
页数:9
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