Phosphodiesterase (PDE)-4 Inhibitors and COPD Correlation with Cancer

被引：1

作者：

Organtzis, John ^{[1
]}

Lampaki, Sofia ^{[1
]}

Zarogoulidis, Paul ^{[1
]}

Huang, Haidong ^{[2
]}

Li, Qiang ^{[2
]}

Papaiwannou, Antonis ^{[1
]}

Syrigos, Konstantinos ^{[3
]}

Porpodis, Konstantinos ^{[1
]}

Tsiouda, Theodora ^{[4
]}

Hohenforst-Schmidt, Wolfgang ^{[5
]}

Trakada, Georgia ^{[6
]}

Walter, Robert Fred Henry ^{[7
,8
]}

Makrantonaki, Dimitra ^{[9
]}

Pitsiou, Georgia ^{[1
]}

Kioumis, Ioannis ^{[1
]}

Zarogoulidis, Konstantinos ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece

[2] II Mil Univ Hosp, Shanghai Hosp, Dept Resp Dis, Shanghai, Peoples R China

[3] Univ Athens, Sotiria Hosp Chest Dis, Dept Oncol, Athens, Greece

[4] Thegeneio Canc Hosp, Dept Internal Med, Thessaloniki, Greece

[5] Univ Wuerzburg,Coburg,Germany, Dept Med 2, Coburg Reg Clin, Coburg, Germany

[6] Natl Univ Athens, Sch Med, Dept Clin Therapeut, Div Pneumonol, Athens, Greece

[7] Univ Duisburg Essen, Univ Hosp Essen, West German Canc Ctr, Ruhrlandklin, Essen, Germany

[8] Univ Duisburg Essen, Univ Hosp Essen, Inst Pathol, Essen, Germany

[9] Theagenio Anticanc Hosp, Dept Internal Med, Thessaloniki, Greece

来源：

JOURNAL OF CANCER | 2014年 / 5卷 / 08期

关键词：

COPD; phosphodiesterase; inflammation; cancer; OBSTRUCTIVE PULMONARY-DISEASE; ROFLUMILAST; INFLAMMATION;

D O I：

10.7150/jca.9730

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new drug for chronic obstructive pulmonary disease has been recently added as a treatment for certain patients. However, new evidences indicate that there might be a connection with lung cancer. It is known that smoking is a major factor that induces chronic pulmonary disease and smoking is associated with lung cancer. The level of connection between phosphodiesterase (PDE)-4 inhibitors and lung cancer will be discussed based on current studies. A comment will be made whether lung cancer is induced to patients receiving phosphodiesterase (PDE)-4 inhibitors from the drug or former smoking habit.

引用

页码：625 / 627

页数：3

共 11 条

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