Nanogels as potential drug nanocarriers for CNS drug delivery

被引：104

作者：

Vashist, Arti ^{[1
]}

Kaushik, Ajeet ^{[1
]}

Vashist, Atul ^{[2
]}

Bala, Jyoti ^{[1
]}

Nikkhah-Moshaie, Roozbeh ^{[1
]}

Sagar, Vidya ^{[1
]}

Nair, Madhavan ^{[1
]}

机构：

[1] Florida Int Univ, Herbert Wertheim Coll Med, Ctr Personalized Nanomed, Inst Neuroimmune Pharmacol,Dept Immunol, Miami, FL 33199 USA

[2] All India Inst Med Sci, Dept Biotechnol, New Delhi 110029, India

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 07期

关键词：

CENTRAL-NERVOUS-SYSTEM; SELF-ASSEMBLED NANOGELS; CHITOSAN NANOGELS; LOADED NANOGELS; IN-VITRO; BRAIN; HYDROGELS; NANOPARTICLES; RELEASE; NANOTECHNOLOGY;

D O I：

10.1016/j.drudis.2018.05.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hydrogel-based drug delivery systems (DDSs) have versatile applications such, as tissue engineering, scaffolds, drug delivery, and regenerative medicines. The drawback of higher size and poor stability in such DDSs are being addressed by developing nano-sized hydrogel particles, known as nanogels, to achieve the desired biocompatibility and encapsulation efficiency for better efficacy than conventional bulk hydrogels. In this review, we describe advances in the development of nanogels and their promotion as nanocarriers to deliver therapeutic agents to the central nervous system (CNS). We also discuss the challenges, possible solutions, and future prospects for the use of nanogel-based DDSs for CNS therapies.

引用

页码：1436 / 1443

页数：8

共 72 条

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