Leveraging algal omics to reveal potential targets for augmenting TAG accumulation

被引：69
作者：
Arora, Neha [1 ]
Pienkos, Philip T. [2 ]
Pruthi, Vikas [1 ]
Poluri, Krishna Mohan [1 ]
Guarnieri, Michael T. [2 ]
机构：
[1] Indian Inst Technol Roorkee, Dept Biotechnol, Uttarakhand 247667, India
[2] Natl Renewable Energy Lab, Natl Bioenergy Ctr, Golden, CO 80401 USA
来源：
BIOTECHNOLOGY ADVANCES | 2018年 / 36卷 / 04期
基金：
美国能源部;
关键词：
Algal; Omics; Triacylglycerol; Transcriptomics; Proteomics; Metabolomic; FLUX BALANCE ANALYSIS; NEUTRAL LIPID-ACCUMULATION; FATTY-ACID-COMPOSITION; CHLAMYDOMONAS-REINHARDTII; NITROGEN STARVATION; CHLORELLA-VULGARIS; PROTEOMIC ANALYSIS; GENE-EXPRESSION; TRIACYLGLYCEROL ACCUMULATION; DUNALIELLA-TERTIOLECTA;
D O I：
10.1016/j.biotechadv.2018.04.005
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Ongoing global efforts to commercialize microalgal biofuels have expedited the use of multi-omics techniques to gain insights into lipid biosynthetic pathways. Functional genomics analyses have recently been employed to complement existing sequence-level omics studies, shedding light on the dynamics of lipid synthesis and its interplay with other cellular metabolic pathways, thus revealing possible targets for metabolic engineering. Here, we review the current status of algal omics studies to reveal potential targets to augment TAG accumulation in various microalgae. This review specifically aims to examine and catalog systems level data related to stress-induced TAG accumulation in oleaginous microalgae and inform future metabolic engineering strategies to develop strains with enhanced bioproductivity, which could pave a path for sustainable green energy.
引用
收藏
页码：1274 / 1292
页数：19
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