Protective effect of Geraniol on the transgenic Drosophila model of Parkinson's disease

被引：45
作者：
Siddique, Yasir Hasan [1 ]
Naz, Falaq [1 ]
Jyoti, Smita [1 ]
Ali, Fahad [1 ]
Fatima, Ambreen [1 ]
Khanam, Rahul Saba [1 ]
机构：
[1] Aligarh Muslim Univ, Dept Zool, Fac Life Sci, Drosophila Transgen Lab,Sect Genet, Aligarh 202002, Uttar Pradesh, India
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2016年 / 43卷
关键词：
Geraniol; Drosophila; Parkinson's disease; LIPID-PEROXIDATION PRODUCTS; ALPHA-SYNUCLEIN; DIETARY SUPPLEMENTATION; OXIDATIVE STRESS; LEAF EXTRACT; GLUTATHIONE HOMEOSTASIS; BRAIN-TISSUE; CURCUMIN; PROTEIN; DOPAMINE;
D O I：
10.1016/j.etap.2016.03.018
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The role of Geraniol was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-alpha S) in the neurons. Geraniol at final concentration of 10, 20 and 40 mu M were mixed in the diet and the flies were allowed to feed on it for 24 days. The effect of geraniol was studied on the climbing ability, activity pattern, lipid peroxidation, protein carbonyl, glutathione, dopamine content, and glutathione-S-transferase activity in the brains of transgenic Drosophila. The exposure of PD model flies to 10, 20 and 40 mu M of geraniol results in a significant delay in the loss of climbing ability (p < 0.05), improved activity pattern reduced the oxidative stress (p < 0.05) in the brains of transgenic Drosophila as compared to unexposed PD model flies. The results suggest that geraniol is potent in reducing the PD symptoms in transgenic Drosophila model of Parkinson's disease. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：225 / 231
页数：7
相关论文
共 66 条
  • [41] Geraniol Ameliorates the Motor Behavior and Neurotrophic Factors Inadequacy in MPTP-Induced Mice Model of Parkinson's Disease
    Rekha, Karamkolly R.
    Selvakumar, Govindasamy P.
    Sethupathy, Subramaniam
    Santha, Karunanidhi
    Sivakamasundari, Ramu Inmozhi
    [J]. JOURNAL OF MOLECULAR NEUROSCIENCE, 2013, 51 (03) : 851 - 862
  • [42] A Single Dopamine Pathway Underlies Progressive Locomotor Deficits in a Drosophila Model of Parkinson Disease
    Riemensperger, Thomas
    Issa, Abdul-Raouf
    Pech, Ulrike
    Coulom, Helene
    My-Van Nguyen
    Cassar, Marlene
    Jacquet, Melanie
    Fiala, Andre
    Birman, Serge
    [J]. CELL REPORTS, 2013, 5 (04): : 952 - 960
  • [43] Analysis of locomotor activity rhythms in Drosophila
    Rosato, Ezio
    Kyriacou, Charalambos P.
    [J]. NATURE PROTOCOLS, 2006, 1 (02) : 559 - 568
  • [44] Comparative genomics of the eukaryotes
    Rubin, GM
    Yandell, MD
    Wortman, JR
    Miklos, GLG
    Nelson, CR
    Hariharan, IK
    Fortini, ME
    Li, PW
    Apweiler, R
    Fleischmann, W
    Cherry, JM
    Henikoff, S
    Skupski, MP
    Misra, S
    Ashburner, M
    Birney, E
    Boguski, MS
    Brody, T
    Brokstein, P
    Celniker, SE
    Chervitz, SA
    Coates, D
    Cravchik, A
    Gabrielian, A
    Galle, RF
    Gelbart, WM
    George, RA
    Goldstein, LSB
    Gong, FC
    Guan, P
    Harris, NL
    Hay, BA
    Hoskins, RA
    Li, JY
    Li, ZY
    Hynes, RO
    Jones, SJM
    Kuehl, PM
    Lemaitre, B
    Littleton, JT
    Morrison, DK
    Mungall, C
    O'Farrell, PH
    Pickeral, OK
    Shue, C
    Vosshall, LB
    Zhang, J
    Zhao, Q
    Zheng, XQH
    Zhong, F
    [J]. SCIENCE, 2000, 287 (5461) : 2204 - 2215
  • [45] FLUOROMETRIC MICROMETHOD FOR SIMULTANEOUS DETERMINATION OF SEROTONIN, NORADRENALINE AND DOPAMINE IN MILLIGRAM AMOUNTS OF BRAIN-TISSUE
    SCHLUMPF, M
    LICHTENSTEIGER, W
    LANGEMANN, H
    WASER, PG
    HEFTI, F
    [J]. BIOCHEMICAL PHARMACOLOGY, 1974, 23 (17) : 2437 - 2446
  • [46] Neurotoxic mode of action of artemisinin
    Schmuck, G
    Roehrdanz, E
    Haynes, RK
    Kahl, R
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) : 821 - 827
  • [47] RELATIONSHIPS BETWEEN INDEXES OF BEHAVIORAL ASYMMETRIES AND NEUROCHEMICAL CHANGES FOLLOWING MESENCEPHALIC 6-HYDROXYDOPAMINE INJECTIONS
    SCHWARTING, RKW
    BONATZ, AE
    CAREY, RJ
    HUSTON, JP
    [J]. BRAIN RESEARCH, 1991, 554 (1-2) : 46 - 55
  • [48] Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease
    Siddique, Yasir Hasan
    Khan, Wasi
    Fatima, Ambreen
    Jyoti, Smita
    Khanam, Saba
    Naz, Falaq
    Rahul
    Ali, Fahad
    Singh, Braj Raj
    Naqvi, Alim Hussain
    [J]. DISEASE MODELS & MECHANISMS, 2016, 9 (01) : 63 - 68
  • [49] Role of Ocimum sanctum leaf extract on dietary supplementation in the transgenic Drosophila model of Parkinson's disease
    Siddique, Yasir Hasan
    Faisal, Mohammad
    Naz, Falaq
    Jyoti, Smita
    Rahul
    [J]. CHINESE JOURNAL OF NATURAL MEDICINES, 2014, 12 (10) : 777 - 781
  • [50] The effect of Bacopa monnieri leaf extract on dietary supplementation in transgenic Drosophila model of Parkinson's disease
    Siddique, Yasir Hasan
    Mujtaba, Syed Faiz
    Faisal, Mohammad
    Jyoti, Smita
    Naz, Falaz
    [J]. EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE, 2014, 6 (05) : 571 - 580
1234567