Protective effect of Geraniol on the transgenic Drosophila model of Parkinson's disease

被引：45
作者：
Siddique, Yasir Hasan [1 ]
Naz, Falaq [1 ]
Jyoti, Smita [1 ]
Ali, Fahad [1 ]
Fatima, Ambreen [1 ]
Khanam, Rahul Saba [1 ]
机构：
[1] Aligarh Muslim Univ, Dept Zool, Fac Life Sci, Drosophila Transgen Lab,Sect Genet, Aligarh 202002, Uttar Pradesh, India
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2016年 / 43卷
关键词：
Geraniol; Drosophila; Parkinson's disease; LIPID-PEROXIDATION PRODUCTS; ALPHA-SYNUCLEIN; DIETARY SUPPLEMENTATION; OXIDATIVE STRESS; LEAF EXTRACT; GLUTATHIONE HOMEOSTASIS; BRAIN-TISSUE; CURCUMIN; PROTEIN; DOPAMINE;
D O I：
10.1016/j.etap.2016.03.018
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The role of Geraniol was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-alpha S) in the neurons. Geraniol at final concentration of 10, 20 and 40 mu M were mixed in the diet and the flies were allowed to feed on it for 24 days. The effect of geraniol was studied on the climbing ability, activity pattern, lipid peroxidation, protein carbonyl, glutathione, dopamine content, and glutathione-S-transferase activity in the brains of transgenic Drosophila. The exposure of PD model flies to 10, 20 and 40 mu M of geraniol results in a significant delay in the loss of climbing ability (p < 0.05), improved activity pattern reduced the oxidative stress (p < 0.05) in the brains of transgenic Drosophila as compared to unexposed PD model flies. The results suggest that geraniol is potent in reducing the PD symptoms in transgenic Drosophila model of Parkinson's disease. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：225 / 231
页数：7
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