Cysteinyl-leukotriene, receptor antagonist prevents urological cancer cell growth through early apoptosis

被引：0
|
作者：
Matsuyama, Masahide [1 ]
Funao, Kiyoaki [1 ]
Kuratukuri, Katsuyuki [1 ]
Tanaka, Tomoaki [1 ]
Kawahito, Yutaka [2 ]
Sano, Hajime [4 ]
Yoshimura, Norio [3 ]
Nakatani, Tatsuya [1 ]
Yoshimura, Rikio [1 ]
机构：
[1] Osaka City Univ, Grad Sch Med, Dept Urol, Osaka 5458585, Japan
[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Inflammat & Immunol, Kyoto 6020841, Japan
[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Transplantat & Regenerat Surg, Kyoto 6020841, Japan
[4] Hyogo Coll Med, Dept Internal Med, Kobe, Hyogo 6638501, Japan
来源：
MOLECULAR MEDICINE REPORTS | 2010年 / 3卷 / 02期
关键词：
cysteinyl-leukotriene; receptor antagonist; urological cancer cells; apoptosis;
D O I：
10.3892/mmr_0000261
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent Studies have demonstrated that the cysteinyl-leukotriene, receptor (Cysl-T1R) antagonist induces the growth arrest of cancer cells through apoptosis. In this Study, we examined the effects of the CysLT,R antagonist oil cell proliferation in Urological cancer cell lines, including renal cell carcinoma, bladder cancer, prostate cancer and testicular cancer cells. The inhibitory effect of the CysLT,R antagonist on the urological cancer cells was investigated using the MTT assay and flow cytometry. The CysLT(1)R antagonist induced a reduction in cell viability with a half-maximal concentration of growth inhibition in all the urological cancer cell lines, and arrested the growth of the cells through early apoptosis. In conclusion, the Cysl-T1R antagonist may mediate potent anti-proliferative effects against urological cancer cells through early apoptosis, and may therefore serve as a novel therapeutic target in the treatment of urological cancer.
引用
收藏
页码：329 / 332
页数：4
相关论文
共 50 条
  • [21] Peroxisome Proliferator-Activated Receptor-γActivated by Ligands Can Inhibit Human Lung Cancer Cell Growth through Induction of Apoptosis
    张敏
    邹萍
    白明
    金阳
    陶晓南
    华中科技大学学报(医学英德文版), 2003, (02) : 138 - 140
  • [22] Peroxisome proliferator-activated receptor-γ activated by ligands can inhibit human lung cancer cell growth through induction of apoptosis
    Zhang Min
    Zou Ping
    Bai Ming
    Jin Yang
    Tao Xiaonan
    Current Medical Science, 2003, 23 (2) : 138 - 140
  • [23] A1 adenosine receptor antagonist induces cell apoptosis in KYSE-30 and YM-1 esophageal cancer cell lines
    Zeynali, Parisa
    Jazi, Marie Saghaeian
    Asadi, Jahanbakhsh
    Jafari, Seyyed Mehdi
    BIOMEDICINE-TAIWAN, 2022, 13 (01): : 54 - 61
  • [24] The NK-1 receptor antagonist L-732,138 induces apoptosis in human gastrointestinal cancer cell lines
    Munoz, Miguel
    Rosso, Marisa
    Covenas, Rafael
    PHARMACOLOGICAL REPORTS, 2017, 69 (04) : 696 - 701
  • [25] The NK-1 receptor antagonist L-732,138 induces apoptosis in human gastrointestinal cancer cell lines
    Miguel Muñoz
    Marisa Rosso
    Rafael Coveñas
    Pharmacological Reports, 2017, 69 : 696 - 701
  • [26] Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells
    Zhao, Ting
    Pan, Hui
    Feng, Yang
    Li, Haizhou
    Zhao, Yang
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 12 (05) : 3301 - 3307
  • [27] ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
    Ma, Xingjie
    Huang, Minlu
    Wang, Zhenqiang
    Liu, Bingya
    Zhu, Zhenggang
    Li, Chen
    JOURNAL OF CANCER, 2016, 7 (01): : 60 - 68
  • [28] Pseudolaric Acid B Induces Growth Inhibition and Caspase-Dependent Apoptosis on Head and Neck Cancer Cell lines through Death Receptor 5
    Choi, Su-Jung
    Ahn, Chi-Hyun
    Yang, In-Hyoung
    Jin, Bohwan
    Lee, Won Woo
    Kim, Ji-Hoon
    Ahn, Min-Hye
    Swarup, Neeti
    Hong, Kyoung-Ok
    Shin, Ji-Ae
    Woo, Nam-Tae
    Hong, Seong Doo
    Lee, Jae-Il
    Cho, Sung-Dae
    MOLECULES, 2019, 24 (20):
  • [29] Curcumin inhibits cell growth and induces cell apoptosis through upregulation of miR-33b in gastric cancer
    Sun, Qianqian
    Zhang, Wenjing
    Guo, Yanjie
    Li, Zhuyao
    Chen, Xiaonan
    Wang, Yuanyuan
    Du, Yuwen
    Zang, Wenqiao
    Zhao, Guoqiang
    TUMOR BIOLOGY, 2016, 37 (10) : 13177 - 13184
  • [30] Vaticanol C, a novel resveratrol tetramer, inhibits cell growth through induction of apoptosis in colon cancer cell lines
    Ito, T
    Akao, Y
    Tanaka, T
    Iinuma, M
    Nozawa, Y
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2002, 25 (01) : 147 - 148
12345