Older HIV-positive patients in the era of highly active antiretroviral therapy: changing of a scenario

被引：43

作者：

Tumbarello, M ^{[1
]}

Rabagliati, R ^{[1
]}

Donati, KD ^{[1
]}

Bertagnolio, S ^{[1
]}

Tamburrini, E ^{[1
]}

Tacconelli, E ^{[1
]}

Cauda, R ^{[1
]}

机构：

[1] Catholic Univ, Dept Infect Dis, Rome, Italy

来源：

AIDS | 2003年 / 17卷 / 01期

关键词：

D O I：

10.1097/00002030-200301030-00020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To determine the impact of highly active antiretroviral therapy (HAART) on the viro-immunological response of older HIV-positive patients, we prospectively selected 58 older cases and 116 younger controls. The CD4 T-cell count at baseline was lower in cases, whereas the HIV viral load was similar in both groups. Cases were more frequently affected by co-morbid conditions. Under HAART, a significant increase in CD4 T-cell numbers was observed in both groups, but there was no statistical difference regarding the response to HAART.

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页码：128 / 131

页数：4

相关论文

共 19 条

[1] Reconstitution of CD4+ T lymphocytes in HIV-infected individuals following antiretroviral therapy [J].

Carcelain, G ;

Debré, P ;

Autran, B .

CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (04) :483-488

[2]

Centers for Disease Control and Prevention (CDC), 1998, MMWR Morb Mortal Wkly Rep, V47, P21

[3] A NEW METHOD OF CLASSIFYING PROGNOSTIC CO-MORBIDITY IN LONGITUDINAL-STUDIES - DEVELOPMENT AND VALIDATION [J].

CHARLSON, ME ;

POMPEI, P ;

ALES, KL ;

MACKENZIE, CR .

JOURNAL OF CHRONIC DISEASES, 1987, 40 (05) :373-383

[4] AIDS and the elderly [J].

Chiao, EY ;

Ries, KM ;

Sande, MA .

CLINICAL INFECTIOUS DISEASES, 1999, 28 (04) :740-745

[5] Usefulness of monitoring HIV drug resistance and adherence in individuals failing highly active antiretroviral therapy: a randomized study (ARGENTA) [J].

Cingolani, A ;

Antinori, A ;

Rizzo, MG ;

Murri, R ;

Ammassari, A ;

Baldini, F ;

Di Giambenedetto, S ;

Cauda, R ;

De Luca, A .

AIDS, 2002, 16 (03) :369-379

[6] Changes in thymic function with age and during the treatment of HIV infection [J].

Douek, DC ;

McFarland, RD ;

Keiser, PH ;

Gage, EA ;

Massey, JM ;

Haynes, BF ;

Polis, MA ;

Haase, AT ;

Feinberg, MB ;

Sullivan, JL ;

Jamieson, BD ;

Zack, JA ;

Picker, LJ ;

Koup, RA .

NATURE, 1998, 396 (6712) :690-695

[7]

FERRO S, 1992, J ACQ IMMUN DEF SYND, V5, P348

[8] Decreased recovery of CD4 lymphocytes in older HIV-infected patients beginning highly active antiretroviral therapy [J].

Goetz, MB ;

Boscardin, WJ ;

Wiley, D ;

Alkasspooles, S .

AIDS, 2001, 15 (12) :1576-1579

[9] Severe premature coronary artery disease with protease inhibitors [J].

Henry, K ;

Melroe, H ;

Huebsch, J ;

Hermundson, J ;

Levine, C ;

Swensen, L ;

Daley, J .

LANCET, 1998, 351 (9112) :1328-1328

[10] Response to highly active antiretroviral therapy in HIV-infected patients aged 60 years or older after 24 months follow-up [J].

Knobel, H ;

Guelar, A ;

Valldecillo, G ;

Carmona, A ;

González, A ;

López-Colomés, JL ;

Saballs, P ;

Gimeno, JL ;

Díez, A .

AIDS, 2001, 15 (12) :1591-1593