Local Anesthetic Lidocaine and Cancer: Insight Into Tumor Progression and Recurrence

被引:29
|
作者
Zhang, Caihui [1 ]
Xie, Cuiyu [1 ]
Lu, Yao [1 ,2 ]
机构
[1] Anhui Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Hefei, Peoples R China
[2] Anhui Med Univ, Ambulatory Surg Ctr, Affiliated Hosp 1, Hefei, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
基金
中国国家自然科学基金;
关键词
lidocaine; cancer; metastasis; recurrence; surgery; tumor; molecular mechanisms; CELLS IN-VITRO; GASTRIC-CANCER; HEPATOCELLULAR-CARCINOMA; PERIOPERATIVE LIDOCAINE; DEOXYRIBONUCLEIC-ACID; INTRAVENOUS LIDOCAINE; INTERNATIONAL AGENCY; ICAM-1; EXPRESSION; NEUROPATHIC PAIN; DOWN-REGULATION;
D O I
10.3389/fonc.2021.669746
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer is a leading contributor to deaths worldwide. Surgery is the primary treatment for resectable cancers. Nonetheless, it also results in inflammatory response, angiogenesis, and stimulated metastasis. Local anesthetic lidocaine can directly and indirectly effect different cancers. The direct mechanisms are inhibiting proliferation and inducing apoptosis via regulating PI3K/AKT/mTOR and caspase-dependent Bax/Bcl2 signaling pathways or repressing cytoskeleton formation. Repression invasion, migration, and angiogenesis through influencing the activation of TNF alpha-dependent, Src-induced AKT/NO/ICAM and VEGF/PI3K/AKT signaling pathways. Moreover, the indirect influences are immune regulation, anti-inflammation, and postoperative pain relief. This review summarizes the latest evidence that revealed potential clinical benefits of lidocaine in cancer treatment to explore the probable molecular mechanisms and the appropriate dose.
引用
收藏
页数:13
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