AC133/CD133/Prominin-1

被引：298

作者：

Shmelkov, SV ^{[1
]}

St Clair, R ^{[1
]}

Lyden, D ^{[1
]}

Rafii, S ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Med Genet, New York, NY 10021 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2005年 / 37卷 / 04期

关键词：

AC133; CD133; Prominin-1;

D O I：

10.1016/j.biocel.2004.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prominin-1, originally found on neuroepithelial stem cells in mice, is a five transmembrane domain cell-surface glycoprotein that localizes to membrane protrusions. Its homologue human Prominin-1 was first isolated from hematopoietic stem cells by a monoclonal antibody recognizing a specific epitope designated as AC133 (CD133). Transcription of Prominin-1 is driven by five tissue-specific alternative promoters resulting in the formation of differentially spliced mRNA isoforms. Prominin-1 is expressed on different types of stem cells, but it is not known if it plays a significant role in key stem cell functional features. Although the biological function of Prominin-1 is not well understood, the AC133 epitope currently serves as a useful marker for the isolation of hematopoietic and endothelial progenitor cells. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：715 / 719

页数：5

共 22 条

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