Transcriptional and epigenetic control of hematopoietic stem cell fate decisions in vertebrates

被引：17
|
作者：
Ding, Yanyan [1 ,2 ,3 ]
Liu, Zhenxin [1 ,2 ,3 ]
Liu, Feng [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China
[2] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
DEVELOPMENTAL BIOLOGY | 2021年 / 475卷
基金：
中国国家自然科学基金;
关键词：
Hematopoietic stem cell development; Signaling; Transcription factors; Single cell omics; Lineage tracing; CBF-BETA; CHROMATIN ACCESSIBILITY; AORTIC ENDOTHELIUM; GENE-EXPRESSION; LINEAGE; RNA; RUNX1; M(6)A; EXPANSION; REVEALS;
D O I：
10.1016/j.ydbio.2021.03.003
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Hematopoietic stem cells (HSCs) are the foundation of adult hematopoiesis that produce all types of mature blood lineages. In vertebrates, HSC development is a stepwise process, coordinately regulated by chromatin architectures and a group of transcriptional and epigenetic regulators. A deeper understanding of the molecular mechanisms governing the generation, expansion, and function of HSCs holds great promise in the generation and expansion of engraftable HSCs in vitro for clinical applications. This study reviewed recent advances in transcriptional and epigenetic control of hematopoietic stem cell fate decisions in vertebrates.
引用
收藏
页码：156 / 164
页数：9
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