Mechanisms of CANCER PAIN

被引：136

作者：

Schmidt, Brian L. ^{[1
]}

Hamamoto, Darryl T. ^{[2
]}

Simone, Donald A.

Wilcox, George L. ^{[3
,4
,5
,6
]}

机构：

[1] Univ Calif San Francisco, Dept Oral & Maxillofacial Surg, Sch Dent, San Francisco, CA 94143 USA

[2] Univ Minnesota, Sch Dent, Dept Diagnost & Biol Sci, Div Oral Med Oral Diag & Oral & Maxillofacial Rad, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dept Neurosci, Ctr Pain Res, Acad Hlth Ctr, Minneapolis, MN USA

[4] Univ Minnesota, Dept Pharmacol, Ctr Pain Res, Acad Hlth Ctr, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Dept Dermatol, Ctr Pain Res, Acad Hlth Ctr, Minneapolis, MN 55455 USA

[6] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA

来源：

MOLECULAR INTERVENTIONS | 2010年 / 10卷 / 03期

关键词：

NERVE GROWTH-FACTOR; ENDOTHELIN-B RECEPTOR; PROTEINASE-ACTIVATED RECEPTOR-2; GENE-RELATED PEPTIDE; DORSAL-HORN NEURONS; HUMAN BREAST-CANCER; RAT SPINAL-CORD; CELLS IN-VITRO; CANNABINOID RECEPTORS; SUBSTANCE-P;

D O I：

10.1124/mi.10.3.7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ongoing and breakthrough pain is a primary concern for the cancer patient. Although the etiology of cancer pain remains unclear, animal models of cancer pain have allowed investigators to unravel some of the cancer-induced neuropathologic processes that occur in the region of tumor growth and in the dorsal horn of the spinal cord. Within the cancer microenvironment, cancer and immune cells produce and secrete mediators that activate and sensitize primary afferent nociceptors. Pursuant to these peripheral changes, nociceptive secondary neurons in spinal cord exhibit increased spontaneous activity and enhanced responsiveness to three modes of noxious stimulation: heat, cold, and mechanical stimuli. As our understanding of the peripheral and central mechanisms that underlie cancer pain improves, targeted analgesics for the cancer patient will likely follow.

引用

页码：164 / 178

页数：15

共 168 条

[1] Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: Studies with remifentanil and lidocaine [J].