The construction of metal centers in proteins by rational design

被引：46

作者：

Hellinga, HW ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA

来源：

FOLDING & DESIGN | 1998年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1359-0278(98)00001-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metalloprotein properties result from the interplay between coordination requirements of the metal center, protein stability, and modulation of the metal center by the surrounding protein matrix. Simple metal centers, which exercise control over the protein by affecting stability or enzyme activity, have been created by rational design. Complex centers, which require control by the protein matrix, have also been constructed.

引用

页码：R1 / R8

页数：8

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