Exploring Fetal Sex Dimorphism in the Risk Factors of Gestational Diabetes Mellitus-A Prospective Cohort Study

被引：9

作者：

Wang, Wen-Juan ^{[1
,2
,3
,5
,6
]}

Zhang, Lin ^{[4
,5
,6
]}

Zhang, Dan-Li ^{[1
,2
,5
,6
]}

Zheng, Tao ^{[4
,5
,6
]}

He, Hua ^{[1
,2
,5
,6
]}

Fang, Fang ^{[1
,2
,5
,6
]}

Zhang, Jun ^{[1
,2
,5
,6
]}

Ouyang, Fengxiu ^{[1
,2
,5
,6
]}

Luo, Zhong-Cheng ^{[1
,2
,3
,5
,6
]}

Shen, Xiaoming ^{[5
,6
]}

Huang, Hong ^{[5
,6
]}

Sun, Kun ^{[5
,6
]}

Wang, Weiye ^{[5
,6
]}

Xu, Weiping ^{[5
,6
]}

Zhu, Hong ^{[5
,6
]}

Li, Fei ^{[5
,6
]}

Dong, Yu ^{[5
,6
]}

Zhou, Chen Chen ^{[5
,6
]}

Huang, Yin ^{[5
,6
]}

Zhang, Jinsong ^{[5
,6
]}

Yan, Chonghuai ^{[5
,6
]}

Shen, Lisong ^{[5
,6
]}

Bao, Yixiao ^{[5
,6
]}

Tian, Ying ^{[7
]}

Chen, Weiwei ^{[8
]}

Zhang, Huijuan ^{[8
]}

Guo, Yu-Na ^{[8
]}

Huang, Xiao-Yi ^{[8
]}

Tong, Chuanliang ^{[8
]}

Xu, Jian ^{[8
]}

Zhang, Yiwen ^{[9
]}

Jiang, Fang ^{[9
]}

Yu, Xiaodan ^{[9
]}

Yu, Guangjun ^{[10
]}

Chen, Jinjin ^{[10
]}

Zhang, Yu ^{[11
]}

Li, Xiaotian ^{[12
]}

Cheng, Haidong ^{[12
]}

Zhang, Qinying ^{[12
]}

Duan, Tao ^{[13
]}

Hua, Jing ^{[13
]}

Xu, Mingqing ^{[14
]}

Peng, Hua ^{[15
]}

机构：

[1] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Pediat, Sch Med,Minist Educ, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Pediat, Sch Med,Shanghai Key Lab, Shanghai, Peoples R China

[3] Univ Toronto, Mt Sinai Hosp, Prosserman Ctr Populat Hlth Res,Inst Hlth Policy, Lunenfeld Tanenbaum Res Inst,Dept Obstet & Gyneco, Toronto, ON, Canada

[4] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Obstet & Gynecol, Sch Med, Shanghai, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Med, Chongming Branch, Shanghai, Peoples R China

[7] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai, Peoples R China

[8] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hosp, Sch Med, Shanghai, Peoples R China

[9] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Shanghai, Peoples R China

[10] Shanghai Childrens Hosp, Shanghai, Peoples R China

[11] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai, Peoples R China

[12] Fudan Univ, Obstet & Gynecol Hosp, Shanghai, Peoples R China

[13] Tongji Univ, Shanghai First Matern & Infant Care Hosp, Shanghai, Peoples R China

[14] Shanghai Jiao Tong Univ, Bio X Inst, Sch Med, Shanghai, Peoples R China

[15] Maternal & Child Hlth Inst Yangpu Dist, Shanghai, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2019年 / 10卷

基金：

中国国家自然科学基金; 加拿大健康研究院;

关键词：

gestational diabetes mellitus; fetal sex; risk factor; prospective cohort; Chinese; MATERNAL RISK; WEIGHT-GAIN; INSULIN-RESISTANCE; PREGNANCY; ASSOCIATION; WOMEN; BABY;

D O I：

10.3389/fendo.2019.00848

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gestational diabetes mellitus (GDM) is a common pregnancy complication. Its etiology remains incompletely understood. Studies in recent years suggest that fetal sex may affect maternal metabolic milieu during pregnancy. We sought to assess whether there is fetal sex dimorphism in the risk factors of GDM. In a prospective pregnancy cohort in Shanghai, China, we studied 2,435 singleton pregnant women without pre-existing diabetes. GDM was diagnosed according to the International Association of Diabetes and Pregnancy Study Groups (IADPSG)' criteria. Log-binomial models were applied to obtain the adjusted relative risk (aRR). A total of 380 (15.6%) women developed GDM. Family history of diabetes was associated with an increased risk of GDM in women bearing a female fetus [aRR 1.74 (1.27-2.40), p < 0.001], but not in women bearing a male fetus (p = 0.68) (test for interaction, p = 0.03). Alcohol drinking was associated with an increased risk of GDM in women bearing a male fetus only (p = 0.023), although the test for interaction did not reach statistical significance (p = 0.055). In conclusion, family history of diabetes was associated with an increased risk of GDM in women bearing a female fetus only in this Chinese pregnancy cohort. There may be a need to consider fetal sex dimorphism in evaluating the risk factors of GDM.

引用

页数：5

共 21 条

[1]

[Anonymous], 2018, Obstet Gynecol, V131, pe49, DOI 10.1097/AOG.0000000000002501

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