Simulation Study of an Ultrasound Retinal Prosthesis With a Novel Contact-Lens Array for Noninvasive Retinal Stimulation

被引:17
作者
Gao, Mengdi [1 ,2 ]
Yu, Yanyan [3 ]
Zhao, Huixia [1 ]
Li, Guofeng [1 ]
Jiang, Hongyang [2 ]
Wang, Congzhi [1 ]
Cai, Feiyan [1 ]
Chan, Leanne Lai-Hang [3 ]
Chiu, Bernard [3 ]
Qian, Wei [2 ]
Qiu, Weibao [1 ]
Zheng, Hairong [1 ]
机构
[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Shenzhen 518055, Peoples R China
[2] Northeastern Univ, Sinodutch Biomed & Informat Engn Sch, Shenyang 110169, Liaoning, Peoples R China
[3] City Univ Hong Kong, Dept Elect Engn, Hong Kong, Hong Kong, Peoples R China
基金
美国国家科学基金会;
关键词
Ultrasound neurostimulation; noninvasive stimulation; ultrasound retinal prosthesis (USRP); contact-lens shape array; multiple-focus neurostimulation; FOCUSED ULTRASOUND; BRAIN-STIMULATION; CHALLENGES; PARAMETERS; BLIND; EYE;
D O I
10.1109/TNSRE.2017.2682923
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Millions of people around the world suffer from varying degrees of vision loss (including complete blindness) because of retinal degenerative diseases. Artificial retinal prosthesis, which is usually based on electrical neurostimulation, is the most advanced technology for different types of retinal degeneration. However, this technology involves placing a device into the eyeball, and such a highly invasive procedure is inevitably highly risk and expensive. Ultrasound has been demonstrated to be a promising technology for noninvasive neurostimulation, making it possible to stimulate the retina and induce action potentials similar to those elicited by light stimulation. However, the technology of ultrasound retinal stimulation still requires considerable developments before it could be applied clinically. This paper proposes a novel contact-lens array transducer for use in an ultrasound retinal prosthesis (USRP). The trans-ducer was designed in the shape of a contact lens so as to facilitate acoustic coupling with the eye liquid. The key parameters of the ultrasound transducer were simulated, and results are presented that indicate the achievement of 2-D pattern generation and that the proposed contact-lens array is suitable for multiple-focus neurostimulation, and can be used in a USRP.
引用
收藏
页码:1605 / 1611
页数:7
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