Clinical updates in adult acute lymphoblastic leukemia

被引：25

作者：

Al Ustwani, Omar ^{[1
]}

Gupta, Neha ^{[2
]}

Bakhribah, Hatoon ^{[1
]}

Griffiths, Elizabeth ^{[1
]}

Wang, Eunice ^{[1
]}

Wetzler, Meir ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Med, Leukemia Sect, Buffalo, NY 14263 USA

[2] SUNY Buffalo, Dept Med, Buffalo, NY 14260 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2016年 / 99卷

关键词：

Acute lymphoblastic leukemia; Adolescents and young adults; Chimeric antigen receptors; Minimal residual disease; Monoclonal antibodies; Philadelphia chromosome; Tyrosine kinase inhibitors; MINIMAL RESIDUAL DISEASE; STEM-CELL TRANSPLANTATION; TERM-FOLLOW-UP; BONE-MARROW-TRANSPLANTATION; ACUTE LYMPHOCYTIC-LEUKEMIA; 1ST COMPLETE REMISSION; HYPER-CVAD; PROGNOSTIC-FACTORS; STANDARD-RISK; GROUP-B;

D O I：

10.1016/j.critrevonc.2015.12.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute lymphoblastic leukemia (ALL) is a clonal disease characterized by B or T lineage. Here we cover the clinical manifestations, pathophysiology and therapy for ALL. Additionally, we will discuss the evidence for minimal residual disease assessment, novel molecular targets and newly developed targeted therapies. The separation of ALL into Philadelphia chromosome positive and recently into Philadelphia like disease represents the most exciting developments in this disease. Finally, the advent of new immunotherapeutic approaches led us to predict that in few years, ALL therapy might be based heavily on non-chemotherapeutic approaches. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：189 / 199

页数：11

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