Docosahexaenoic acid induces apoptosis via the bax-independent pathway in HL-60 cells

被引：12

作者：

Miura, Y

Takahara, K

Murata, Y

Utsumi, K

Tada, M

Takahata, K

机构：

[1] Okayama Univ, Fac Agr, Okayama 7008530, Japan

[2] Kurashiki Med Ctr, Inst Med Sci, Kurashiki, Okayama 7108552, Japan

[3] Okayama Univ, Grad Sch Natl Sci & Technol, Okayama 7008530, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2004年 / 68卷 / 11期

关键词：

docosahexaenoic acid (DHA); apoptosis; bax; caspase-3; HL-60; cells;

D O I：

10.1271/bbb.68.2415

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We attempted to determine whether docosahexaenoic acid (DHA)-induced apoptosis is mediated via the Bax-mediated pathway in human myeloid leukemia HL-60 cells. DHA-induced apoptosis was confirmed by morphological analysis and caspase-3 activation. But, cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition (MPT), did not inhibit DHA-induced Bax translocation to mitochondria or caspase-3 activation. These data suggest that DHA can induce apoptosis via the Bax-independent pathway.

引用

页码：2415 / 2417

页数：3

共 11 条

[1] Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway [J].