Expression of ETS-1 related to angiogenesis in uterine endometrium during the menstrual cycle

被引：22

作者：

Fujimoto, J ^{[1
]}

Aoki, I ^{[1
]}

Toyoki, H ^{[1
]}

Khatun, S ^{[1
]}

Sato, E ^{[1
]}

Tamaya, T ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Obstet & Gynecol, Gifu 5008705, Japan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2003年 / 10卷 / 03期

关键词：

angiogenesis; ets-1; uterine endometrium;

D O I：

10.1159/000070097

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ETS-1 has been identified as a transcription factor for angiogenesis, which is essential for the development and growth of the uterine endometrium. This characteristic prompted us to study whether ETS-1 functions as an angiogenic mediator in uterine endometrium. Immunohistochemical staining revealed that the localization of ETS-1 was similar to that of vascular endothelial cells. There was a significant correlation between microvessel counts and both ETS-1 histoscores and ets-1 mRNA levels in uterine endometrium. The ETS-1 histoscores and ets-1 mRNA levels increased in the proliferative phase, reached a peak during peri-ovulation and decreased in the secretory phase. Furthermore, the ETS-1 histoscores and ets-1 mRNA levels correlated with vascular endothelial growth factor (VEGF) levels in the proliferative phase. This indicates that ETS-1 might be an angiogenic mediator in uterine endometrium linked to VEGF in the proliferative phase. Copyright (C) 2003 National Science Council, ROC and S. Karger AG, Basel.

引用

页码：320 / 327

页数：8

共 32 条

[1] A dynamic shift of VEGF isoforms with a transient and selective progesterone-induced expression of VEGF189 regulates angiogenesis and vascular permeability in human uterus [J].

Ancelin, M ;

Buteau-Lozano, H ;

Meduri, G ;

Osborne-Pellegrin, M ;

Sordello, S ;

Plouët, J ;

Perrot-Applanat, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (09) :6023-6028

[2]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[3] Expression of topoisomerase IIα, Ki-67, proliferating cell nuclear antigen, p53, and argyrophilic nucleolar organizer regions in vulvar squamous lesions [J].

Brustmann, H ;

Naudé, S .

GYNECOLOGIC ONCOLOGY, 2002, 86 (02) :192-199

[4] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[5]

DENEKAMP J, 1984, PROG APPLIED MICROCI, V4, P28

[6] Clinical implications of expression of ETS-1 related to angiogenesis in uterine cervical cancers [J].

Fujimoto, J ;

Aoki, I ;

Toyoki, H ;

Khatun, S ;

Tamaya, T .

ANNALS OF ONCOLOGY, 2002, 13 (10) :1598-1604

[7] Expression of platelet-derived endothelial cell growth factor and its mRNA in uterine endometrium during the menstrual cycle [J].

Fujimoto, J ;

Ichigo, S ;

Sakaguchi, H ;

Hirose, R ;

Tamaya, T .

MOLECULAR HUMAN REPRODUCTION, 1998, 4 (05) :509-513

[8] Expression of basic fibroblast growth factor and its mRNA in uterine endometrium during the menstrual cycle [J].

Fujimoto, J ;

Hori, M ;

Ichigo, S ;

Tamaya, T .

GYNECOLOGICAL ENDOCRINOLOGY, 1996, 10 (03) :193-197

[9] VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) IN PRIMATE ENDOMETRIUM - IMMUNOHISTOCHEMICAL PATTERNS DURING THE CYCLE AND AFTER CHRONIC RU-486 TREATMENT IN CYNOMOLGUS MONKEYS [J].

GREB, RR ;

BUKOWSKI, R ;

HSIU, JG ;

WILLIAMS, RF ;

HODGEN, GD ;

GOODMAN, AL .

STEROID RECEPTORS AND ANTIHORMONES, 1995, 761 :376-382

[10] The role of selective oestrogen receptor modulators in the treatment of endometrial bleeding in women using long-acting progestin contraception [J].

Grow, DR ;

Reece, MT .

HUMAN REPRODUCTION, 2000, 15 :30-38

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