The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells

被引：20

作者：

Aliwaini, Saeb ^{[1
]}

Peres, Jade ^{[1
]}

Kroeger, Wendy L. ^{[1
]}

Blanckenberg, Angelique ^{[2
]}

de la Mare, Jo ^{[3
]}

Edkins, Adrienne L. ^{[3
]}

Mapolie, Selwyn ^{[2
]}

Prince, Sharon ^{[1
]}

机构：

[1] Univ Cape Town, Dept Human Biol, Fac Hlth Sci, ZA-7925 Cape Town, South Africa

[2] Univ Stellenbosch, Dept Chem & Polymer Sci, ZA-7600 Stellenbosch, South Africa

[3] Rhodes Univ, Biomed Biotechnol Res Unit, Dept Biochem Microbiol & Biotechnol, ZA-6140 Grahamstown, South Africa

来源：

CANCER LETTERS | 2015年 / 357卷 / 01期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

Palladacycles; Breast cancer; Cancer stem cells; Apoptosis; Autophagy; p38; MAPK; ACUTE PROMYELOCYTIC LEUKEMIA; CASPASE-MEDIATED CLEAVAGE; IN-VITRO; CHEMOTHERAPEUTIC-AGENT; CISPLATIN RESISTANCE; ARSENIC TRIOXIDE; APOPTOSIS; AUTOPHAGY; DEATH; COMPLEX;

D O I：

10.1016/j.canlet.2014.11.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most common malignancy amongst women worldwide but despite enormous efforts to address this problem, there is still limited success with most of the current therapeutic strategies. The current study describes the anti-cancer activity of a binuclear palladacycle complex (AJ-5) in oestrogen receptor positive (MCF7) and oestrogen receptor negative (MDA-MB-231) breast cancer cells as well as human breast cancer stem cells. AJ-5 is shown to induce DNA double strand breaks leading to intrinsic and extrinsic apoptosis and autophagy cell death pathways which are mediated by the p38 MAP kinase. This study provides evidence that AJ-5 is potentially an effective compound in the treatment of breast cancer. (c) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：206 / 218

页数：13

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