The role of metalloproteinases in endometrial remodelling during menstrual cycle

被引:14
作者
Grzechocinska, Barbara [1 ]
Dabrowski, Filip [1 ]
Cyganek, Anna [1 ]
Panek, Grzegorz [1 ]
Wielgos, Miroslaw [1 ]
机构
[1] Med Univ Warsaw, Dept Obstet & Gynecol, Fac Med 1, Warsaw, Poland
关键词
extracellular matrix metalloproteinases ( MMPs); tissue inhibitors of metalloproteinases (TIMPs); endometrium; bleeding; MATRIX-METALLOPROTEINASES; TISSUE INHIBITORS; OVARIAN-STEROIDS; EXTRACELLULAR-MATRIX; CANCER PROGRESSION; EXPRESSION; CELLS; MATRIX-METALLOPROTEINASE-9; LEVONORGESTREL; ACTIVATION;
D O I
10.5603/GP.a2017.0063
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Endometrial is the only tissue in the human body subject to cyclic transformations under the influence of ovarian steroid hormones. As estradiol and progesterone balance throughout the physiological menstrual cycle changes, so does the expression of metalloproteinases (MMPs). These endopeptides are responsible for keeping the balance between the process of synthesis and degradation of extracellular matrix proteins. Thus, MMP's take part in sustaining physiological stability of the endometrium. A number of MMPs found in the endometrial tissue and their activity is related to menstrual cycle phase. This paper is an up-to-date review of literature of Medline database. The search was conducted for key words including "matrix metalloproteinases", "MMPs", "TIMPs" and "tissue inhibitors of metalloproteinases". Over 1092 publications regarding interdependence and interplay between ovarian hormones and the role of various MMPs and their inhibitors in normal endometrial remodelling and in pathological conditions were analysed and critically reviewed.
引用
收藏
页码:337 / 342
页数:6
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