Excitability of Upper Layer Circuits Relates to Torque Output in Humans

被引:6
作者
Kurz, Alexander [1 ,2 ]
Leukel, Christian [1 ,2 ]
机构
[1] Univ Freiburg, Dept Sport Sci, Freiburg, Germany
[2] Univ Freiburg, Bernstein Ctr Freiburg, Freiburg, Germany
来源
FRONTIERS IN HUMAN NEUROSCIENCE | 2019年 / 13卷
关键词
M1; laminar; human; TMS; nerve stimulation; motor control; force output; MAGNETIC BRAIN-STIMULATION; MOTOR CORTEX; CORTICOMOTONEURONAL CELLS; SPINAL-CORD; CORTICOSPINAL NEURONS; PRECENTRAL CORTEX; FORCE; ORGANIZATION; RESPONSES; INPUT;
D O I
10.3389/fnhum.2019.00359
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The relation between primary motor cortex (M1) activity and (muscular) force output has been studied extensively. Results from previous studies indicate that activity of a part of yet unidentified neurons in M1 are positively correlated with increased force levels. One considerable candidate causing this positive correlation could be circuits at supragranular layers. Here we tested this hypothesis and used the combination of H-reflexes with transcranial magnetic stimulation (TMS) to investigate laminar associations with force output in human subjects. Excitability of different M1 circuits were probed at movement onset and at peak torque while participants performed auxotonic contractions of the wrist with different torque levels. Only at peak torque we found a significant positive correlation between excitability of M1 circuits most likely involving neurons at supragranular layers and joint torque level. We argue that this finding may relate to the special role of upper layer circuits in integrating (force-related) afferent feedback and their connectivity with task-relevant pyramidal and also extrapyramidal pathways projecting to motoneurones in the spinal cord.
引用
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页数:9
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