Novel 2-pyrone synthesis via Michael addition of mandelic acid enolate to trans-1,2-diaroylethenes

被引：9

作者：

Barroso, S ^{[1
]}

Blay, G ^{[1
]}

Fernández, I ^{[1
]}

Pedro, JR ^{[1
]}

机构：

[1] Univ Valencia, Fac Quim, Dept Quim Organ, E-46100 Burjassot, Valencia, Spain

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 46期

关键词：

dioxolanone; lactones; enones; hydroxyacids;

D O I：

10.1016/j.tetlet.2004.09.052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Aroyl-6-aryl-3-phenyl-2-pyrones are prepared in a three-step procedure involving the Michael addition of a cis-2,5-disubstituted-1,3-dioxolan-4-one, derived from mandelic acid, to trans-1,2-diaroylethenes, cyclisation to a furan under acidic conditions and lactonisation. The 2-pyrones can be also obtained directly from the Michael products under prolonged or strong acidic treatment with little decrease in yield. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8583 / 8586

页数：4

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