Lack of translation of normal 7B2 mRNA levels in hypothalamic mutant vasopressin cells of the homozygous Brattleboro rat

被引：3

作者：

Gabreëls, BATF ^{[1
]}

Verwer, RWH ^{[1
]}

Sonnemans, MAF ^{[1
]}

Sluiter, AA ^{[1
]}

Ang, CW ^{[1
]}

van Leeuwen, FW ^{[1
]}

机构：

[1] Netherlands Inst Brain Res, Grad Sch Neurosci, NL-1105 AZ Amsterdam, Netherlands

来源：

NEUROSCIENCE LETTERS | 1997年 / 239卷 / 01期

关键词：

oxytocin; compartmentalization; endoplasmic reticulum; translocon; in situ hybridization;

D O I：

10.1016/S0304-3940(97)00883-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with an aberrant C-terminus, which causes a hypothalamic form of diabetes insipidus. The neuroendocrine polypeptide 7B2 is present in VP and oxytocin (OT) neurons of the supraoptic and paraventricular nucleus of the hypothalamus in wild type rats. However, in the di/di rat 7B2 immunoreactivity is absent in the VP cell population, whereas 7B2 levels within the OT cells are unaffected. Remarkably, there is no obvious difference in 7B2 transcript levels between VP and OT neurons in the di/di rat hypothalamus. This study shows that the presence of mRNA does not automatically result in the subsequent synthesis of its protein. Cellular mechanisms underlying this discrepancy are discussed. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：5 / 8

页数：4

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