RETRACTED: MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling(Retracted article.See vol.36,Article 61,2017)

被引：24

作者：

Chu, Shao-Jun ^{[1
]}

Wang, Ge ^{[2
]}

Zhang, Peng-Fei ^{[2
]}

Zhang, Rui ^{[2
]}

Huang, Yan-Xia ^{[2
]}

Lu, Yun-Min ^{[2
]}

Da, Wei ^{[2
]}

Sun, Qun ^{[2
]}

Zhang, Jing ^{[2
]}

Zhu, Jin-Shui ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Shanghai Peoples Hosp 6, Dept Gerontol, Shanghai 200233, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Shanghai Peoples Hosp 6, Dept Gastroenterol, Yishan Rd 600, Shanghai 200233, Peoples R China

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2016年 / 35卷

关键词：

miRNA-203; Growth; Gastric cancer; PIBF1; Akt; INDUCED BLOCKING FACTOR; TUMOR-GROWTH; MIR-203; INVASION; METASTASIS; PROLIFERATION; PROGNOSIS; MIRNA-203; CELLS;

D O I：

10.1186/s13046-016-0323-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive. Results: Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression. Conclusions: MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC.

引用

页数：11

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