Immunity-Related Protein Expression and Pathological Lung Damage in Mice Poststimulation with Ambient Particulate Matter from Live Bird Markets

被引:14
作者
Meng, Kai [1 ,2 ]
Wu, Bo [1 ]
Gao, Jing [3 ]
Cai, Yumei [1 ]
Yao, Meiling [4 ]
Wei, Liangmeng [1 ,2 ]
Chai, Tongjie [1 ,2 ]
机构
[1] Shandong Agr Univ, Coll Vet Med, Sino German Cooperat Res Ctr Zoonosis Anim Origin, Tai An, Shandong, Peoples R China
[2] Taishan Med Coll, Collaborat Innovat Ctr Origin & Control Emerging, Tai An, Shandong, Peoples R China
[3] Taian Cent Hosp, Tai An, Shandong, Peoples R China
[4] Zaozhuang Vocat Coll, Shandong, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2016年 / 7卷
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
particulate matter; biological material; live bird market; immunity-related protein; lung injury; TOLL-LIKE RECEPTOR; INFLUENZA-A H7N9; HUMAN INFECTIONS; POULTRY MARKETS; PARTICLE-SIZE; VIRUS; MICROORGANISMS; EPIDEMIOLOGY; AEROSOLS; INJURY;
D O I
10.3389/fimmu.2016.00252
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The objective of this study was to obtain insight into the adverse health effects of airborne particulate matter (PM) collected from live bird markets and to determine whether biological material in PM accounts for immune-related inflammatory response. Mice were exposed to a single or repeated dose of PM, after which the expression of toll-like receptors (TLRs), cytokines, and chemokines in the lungs of infected mice were examined by enzyme-linked immunosorbent assay and histopathological analysis. Results after single and repeated PM stimulation with PM2.5+, PM2-5-, PM10+, and PM10- indicated that TLR2 and TLR4 played a dominant role in the inflammatory responses of the lung. Further analysis demonstrated that the expression levels of IL-1 beta, TNF-alpha, IFN-gamma, IL-8, IP-10, and MCP-1 increased significantly, which could eventually contribute to lung injury. Moreover, biological components in PM were critical in mediating immune-related inflammatory responses and should therefore not be overlooked.
引用
收藏
页码:1 / 12
页数:12
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