Programmed cell death-1 3-untranslated region polymorphism is associated with spontaneous clearance of hepatitis B virus infection

被引：14

作者：

Chihab, Hajar ^{[1
,2
]}

Jadid, Fatima-Zahra ^{[1
]}

Foka, Pelagia ^{[3
]}

Zaidane, Imane ^{[1
]}

El Fihry, Raouia ^{[1
]}

Georgopoulou, Urania ^{[3
]}

Marchio, Agnes ^{[4
]}

Elhabazi, Abdellah ^{[2
]}

Chair, Mohammed ^{[2
]}

Pineau, Pascal ^{[4
]}

Ezzikouri, Sayeh ^{[1
]}

Benjelloun, Soumaya ^{[1
]}

机构：

[1] Inst Pasteur Maroc, Viral Hepatitis Lab, Virol Unit, 1 Pl Louis Pasteur, Casablanca 20360, Morocco

[2] Univ Chouaib Doukkali, Fac Sci El Jadida, Lab Biotechnol Biochim & Nutr, El Jadida, Morocco

[3] Hellenic Pasteur Inst, Mol Virol Lab, Athens, Greece

[4] Inst Pasteur, INSERM U993, Unite Org Nucl & Oncogenese, Paris, France

来源：

JOURNAL OF MEDICAL VIROLOGY | 2018年 / 90卷 / 11期

关键词：

chronic hepatitis B virus infection; programmed cell death-1; PD-1; polymorphism; spontaneous clearance; CD8(+) T-CELLS; PD-1; EXPRESSION; GENE POLYMORPHISMS; IMMUNE-RESPONSE; B7-CD28; FAMILY; HCV INFECTION; PD1; SUSCEPTIBILITY; DYSFUNCTION; RESTORATION;

D O I：

10.1002/jmv.25265

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis B virus (HBV)-specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death-1 (PD-1), an immunosuppressive molecule that regulates T-cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525, a single-nucleotide polymorphism in the 3-untranslated region (3-UTR) of PD-1, has been associated with susceptibility and disease progression of chronic HBV infection in far-eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients. A total of 236 patients with chronic HBV infection and 134 individuals with spontaneous HBV resolution were genotyped using a Taqman assay. In addition, PD-1 mRNA expression in peripheral blood nuclear cells was determined by quantitativereverse-transcription polymerase chain reaction. We found that the AA genotype is protective (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.97; P=0.038) against HBV infection. Interestingly, PD-1 messenger RNA (mRNA) expression analysis has revealed that chronic HBV carriers with GG and GA displayed higher levels of PD-1 mRNA compared with corresponding genotypes in resolved subjects (P=0.031 and0.014, respectively). Our data suggest that Mediterranean HBV-infected patients carrying PD-1 GG and GA genotypes at rs10204525 have high PD-1 mRNA expression and may be more prone to installation of chronicity.

引用

页码：1730 / 1738

页数：9

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