Exploring genetic interactions and networks with yeast

被引：425

作者：

Boone, Charles

Bussey, Howard

Andrews, Brenda J.

机构：

[1] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5S 3E1, Canada

[2] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol, Toronto, ON M5S 3E1, Canada

[3] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 06期

基金：

加拿大健康研究院;

关键词：

SYNTHETIC LETHAL ANALYSIS; SACCHAROMYCES-CEREVISIAE; FUNCTIONAL GENOMICS; PROTEIN COMPLEXES; IDENTIFY GENES; CELL; IDENTIFICATION; POLYMORPHISMS; EXPLORATION; EXPRESSION;

D O I：

10.1038/nrg2085

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The development and application of genetic tools and resources has enabled a partial genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis of the network, which is ongoing, has already provided a clear picture of the nature and scale of the genetic interactions that robustly sustain biological systems, and how cellular buffering is achieved at the molecular level. Recent studies in yeast have begun to define general principles of genetic networks, and also pave the way for similar studies in metazoan model systems. A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease.

引用

页码：437 / 449

页数：13

共 88 条

[1] A haplotype map of the human genome [J].

Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

NATURE, 2005, 437 (7063) :1299-1320

[2]

AVERY L, 1992, TRENDS GENET, V8, P312, DOI 10.1016/0168-9525(92)90263-4

[3] The centrosome in human genetic disease [J].

Badano, JL ;

Teslovich, TM ;

Katsanis, N .

NATURE REVIEWS GENETICS, 2005, 6 (03) :194-205

[4] Functional genomics and proteomics: charting a multidimensional map of the yeast cell [J].

Bader, GD ;

Heilbut, A ;

Andrews, B ;

Tyers, M ;

Hughes, T ;

Boone, C .

TRENDS IN CELL BIOLOGY, 2003, 13 (07) :344-356

[5]

BAKER BS, 1980, GENETICS, V94, P383

[6] Scale-free networks [J].

Barabási, AL ;

Bonabeau, E .

SCIENTIFIC AMERICAN, 2003, 288 (05) :60-69

[7]

BASSON ME, 1987, GENETICS, V117, P645

[8] Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions -: art. no. R45 [J].

Baugh, LR ;

Wen, JC ;

Hill, AA ;

Slonim, DK ;

Brown, EL ;

Hunter, CP .

GENOME BIOLOGY, 2005, 6 (05)

[9] USE OF A SCREEN FOR SYNTHETIC LETHAL AND MULTICOPY SUPPRESSEE MUTANTS TO IDENTIFY 2 NEW GENES INVOLVED IN MORPHOGENESIS IN SACCHAROMYCES-CEREVISIAE [J].

BENDER, A ;

PRINGLE, JR .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (03) :1295-1305

[10] Systematic discovery of multicomponent therapeutics [J].

Borisy, AA ;

Elliott, PJ ;

Hurst, NW ;

Lee, MS ;

Lehár, J ;

Price, ER ;

Serbedzija, G ;

Zimmermann, GR ;

Foley, MA ;

Stockwell, BR ;

Keith, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) :7977-7982

← 1 2 3 4 5 6 7 8 9 →