(+)-2-methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors

被引：111
作者：
Clark, BP
Baker, SR
Goldsworthy, J
Harris, JR
Kingston, AE
机构：
[1] Eli Lilly and Co., Lilly Research Centre Ltd., Windlesham, Surrey GU20 6PH, Erl Wood Manor
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期
关键词：
D O I：
10.1016/S0960-894X(97)10071-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of three novel 4-carboxyphenylglycine derivatives is described. 2-Methyl substituents increase the antagonist potency compared to (S)-4CPG at mGluR1 receptors. Resolution of compound 1 showed that the activity resided in the (+)-isomer LY367385. (C) 1997 Elsevier Science Ltd.
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页码：2777 / 2780
页数：4
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