(+)-2-methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors

被引：112

作者：

Clark, BP

Baker, SR

Goldsworthy, J

Harris, JR

Kingston, AE

机构：

[1] Eli Lilly and Co., Lilly Research Centre Ltd., Windlesham, Surrey GU20 6PH, Erl Wood Manor

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(97)10071-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of three novel 4-carboxyphenylglycine derivatives is described. 2-Methyl substituents increase the antagonist potency compared to (S)-4CPG at mGluR1 receptors. Resolution of compound 1 showed that the activity resided in the (+)-isomer LY367385. (C) 1997 Elsevier Science Ltd.

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页码：2777 / 2780

页数：4

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