A Novel Method to Measure Venular Perivascular Spaces in Patients with MS on 7T MRI

被引：11
|
作者：
George, I. C. [1 ]
Arrighi-Allisan, A. [2 ]
Delman, B. N. [3 ]
Balchandani, P. [3 ,4 ,5 ]
Horng, S. [6 ]
Feldman, R. [7 ,8 ,9 ,10 ]
机构：
[1] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
[2] Icahn Sch Med Mt Sinai, Dept Med Educ, New York, NY 10029 USA
[3] Icahn Sch Med Mt Sinai, Dept Diagnost Mol & Intervent Radiol, New York, NY 10029 USA
[4] Icahn Sch Med Mt Sinai, Dept Neurosci & Psychiat, New York, NY 10029 USA
[5] Icahn Sch Med Mt Sinai, BioMed Engn & Imaging Inst, New York, NY 10029 USA
[6] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA
[7] Univ British Columbia, Dept Comp Sci, Kelowna, BC, Canada
[8] Univ British Columbia, Dept Math, Kelowna, BC, Canada
[9] Univ British Columbia, Dept Phys, Kelowna, BC, Canada
[10] Univ British Columbia, Dept Stat, Kelowna, BC, Canada
来源：
AMERICAN JOURNAL OF NEURORADIOLOGY | 2021年 / 42卷 / 06期
基金：
美国国家卫生研究院;
关键词：
MULTIPLE-SCLEROSIS; DIAGNOSIS; MARKER;
D O I：
10.3174/ajnr.A7144
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In MS, inflammatory cells accumulate within the perivascular spaces of acute and chronic lesions. Reliance on perivascular spaces as biomarkers for MS remains uncertain because various studies have reported inconsistencies in perivascular space anatomy. Distinguishing between venular and arteriolar perivascular spaces is pathophysiologically relevant in MS. In this pilot study, we leverage susceptibility-weighted imaging at 7T to better identify perivascular spaces of venular distribution on corresponding high-resolution T2 images.
引用
收藏
页码：1069 / 1072
页数：4
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