Screening of a combinatorial steroid library using molecularly imprinted polymers

被引:91
作者
Ramstrom, O [1 ]
Ye, L [1 ]
Krook, M [1 ]
Mosbach, K [1 ]
机构
[1] Univ Lund, Ctr Chem & Chem Engn, SE-22100 Lund, Sweden
来源
ANALYTICAL COMMUNICATIONS | 1998年 / 35卷 / 01期
关键词
D O I
10.1039/a707876e
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Molecular imprinting is an attractive method for producing highly selective adsorbents, and several new and potentially useful applications based on molecularly imprinted polymers (MIPs) have been described in recent years. In this article, we introduce a new field of application in which the selectivities of imprinted materials can be gainfully employed as binding matrices in the screening of combinatorial libraries. MIPs prepared against androstenone structures could be efficiently employed to select these compounds from a combinatorial library.
引用
收藏
页码:9 / 11
页数:3
相关论文
共 16 条
[1]  
Allenmark StigG., 1988, CHROMATOGRAPHIC ENAN
[2]   Application of molecular imprinting to the development of aqueous buffer and organic solvent based radioligand binding assays for (S)-propranolol [J].
Andersson, LI .
ANALYTICAL CHEMISTRY, 1996, 68 (01) :111-117
[3]   MIMICS OF THE BINDING-SITES OF OPIOID RECEPTORS OBTAINED BY MOLECULAR IMPRINTING OF ENKEPHALIN AND MORPHINE [J].
ANDERSSON, LI ;
MULLER, R ;
VLATAKIS, G ;
MOSBACH, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4788-4792
[4]   Selection of phage display combinatorial library peptides with affinity for a yohimbine imprinted methacrylate polymer [J].
Berglund, J ;
Lindbladh, C ;
Nicholls, IA ;
Mosbach, K .
ANALYTICAL COMMUNICATIONS, 1998, 35 (01) :3-7
[5]   SOLUBLE COMBINATORIAL LIBRARIES OF ORGANIC, PEPTIDOMIMETIC AND PEPTIDE DIVERSITIES [J].
BLONDELLE, SE ;
PEREZPAYA, E ;
DOOLEY, CT ;
PINILLA, C ;
HOUGHTEN, RA .
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 1995, 14 (02) :83-92
[6]  
Fenniri H, 1996, CURR MED CHEM, V3, P343
[7]   USE OF SILANE MONOMERS FOR MOLECULAR IMPRINTING AND ENZYME ENTRAPMENT IN POLYSILOXANE-COATED POROUS SILICA [J].
GLAD, M ;
NORRLOW, O ;
SELLERGREN, B ;
SIEGBAHN, N ;
MOSBACH, K .
JOURNAL OF CHROMATOGRAPHY, 1985, 347 (01) :11-23
[8]   Antibody-Mimicking polymers as chiral stationary phases in HPLC [J].
Kempe, M .
ANALYTICAL CHEMISTRY, 1996, 68 (11) :1948-1953
[9]   The emerging technique of molecular imprinting and its future impact on biotechnology [J].
Mosbach, K ;
Ramstrom, O .
BIO-TECHNOLOGY, 1996, 14 (02) :163-170
[10]   Artificial antibodies to corticosteroids prepared by molecular imprinting [J].
Ramstrom, O ;
Ye, L ;
Mosbach, K .
CHEMISTRY & BIOLOGY, 1996, 3 (06) :471-477