How are TH2-type immune responses initiated and amplified?

被引：728

作者：

Paul, William E. ^{[1
]}

Zhu, Jinfang ^{[1
]}

机构：

[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 04期

基金：

美国国家卫生研究院;

关键词：

THYMIC STROMAL LYMPHOPOIETIN; T-HELPER-CELL; TRANSCRIPTION FACTOR GATA-3; EOSINOPHIL-DERIVED NEUROTOXIN; MYELOID DENDRITIC CELLS; HUMAN EPITHELIAL-CELLS; IN-VIVO; CUTTING EDGE; TH2; CELLS; PRODUCE INTERLEUKIN-4;

D O I：

10.1038/nri2735

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+) T helper (T-H) cells have crucial roles in orchestrating adaptive immune responses. T(H)2 cells control immunity to extracellular parasites and all forms of allergic inflammatory responses. Although we understand the initiation of the T(H)2-type response in tissue culture in great detail, much less is known about T(H)2 cell induction in vivo. Here we discuss the involvement of allergen-and parasite product-mediated activation of epithelial cells, basophils and dendritic cells and the functions of the cytokines interleukin-4 (IL-4), IL-25, IL-33 and thymic stromal lymphopoietin in the initiation and amplification of T(H)2-type immune responses in vivo.

引用

收藏

页码：225 / 235

页数：11

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