Continental-scale pollution of estuaries with antibiotic resistance genes

被引:941
作者
Zhu, Yong-Guan [1 ,2 ]
Zhao, Yi [1 ]
Li, Bing [3 ]
Huang, Chu-Long
Zhang, Si-Yu [2 ]
Yu, Shen [1 ]
Chen, Yong-Shan [1 ]
Zhang, Tong [4 ]
Gillings, Michael R. [5 ]
Su, Jian-Qiang
机构
[1] Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China
[2] Chinese Acad Sci, Res Ctr Eco Environm Sci, State Key Lab Urban & Reg Ecol, Beijing, Peoples R China
[3] Tsinghua Univ, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China
[4] Univ Hong Kong, Dept Civil Engn, Environm Biotechnol Lab, Hong Kong, Hong Kong, Peoples R China
[5] Macquarie Univ, Dept Biol Sci, Genes Geosci Res Ctr, Sydney, NSW 2109, Australia
基金
对外科技合作项目(国际科技项目);
关键词
WASTE-WATER; RIVER ESTUARY; CHINA; VANCOMYCIN; RESISTOME; INTEGRONS; ENVIRONMENT; SEDIMENT; BACTERIA; IMPACTS;
D O I
10.1038/nmicrobiol.2016.270
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Antibiotic resistance genes (ARGs) have moved from the environmental resistome into human commensals and pathogens, driven by human selection with antimicrobial agents. These genes have increased in abundance in humans and domestic animals, to become common components of waste streams. Estuarine habitats lie between terrestrial/freshwater and marine ecosystems, acting as natural filtering points for pollutants. Here, we have profiled ARGs in sediments from 18 estuaries over 4,000 km of coastal China using high-throughput quantitative polymerase chain reaction, and investigated their relationship with bacterial communities, antibiotic residues and socio-economic factors. ARGs in estuarine sediments were diverse and abundant, with over 200 different resistance genes being detected, 18 of which were found in all 90 sediment samples. The strong correlations of identified resistance genes with known mobile elements, network analyses and partial redundancy analysis all led to the conclusion that human activity is responsible for the abundance and dissemination of these ARGs. Such widespread pollution with xenogenetic elements has environmental, agricultural and medical consequences.
引用
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页数:7
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