Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

被引：159

作者：

Minutti, Carlos M. ^{[1
,2
,3
,4
]}

Jackson-Jones, Lucy H. ^{[3
,4
]}

Garcia-Fojeda, Belen ^{[1
,2
]}

Knipper, Johanna A. ^{[3
,4
]}

Sutherland, Tara E. ^{[3
,4
,5
]}

Logan, Nicola ^{[3
,4
]}

Rinqvist, Emma ^{[3
,4
,11
]}

Guillamat-Prats, Raquel ^{[2
,6
]}

Ferenbach, David A. ^{[3
,4
]}

Artigas, Antonio ^{[2
,6
]}

Stamme, Cordula ^{[7
,8
]}

Chroneos, Zissis C. ^{[9
]}

Zaiss, Dietmar M. ^{[3
,4
]}

Casals, Cristina ^{[1
,2
]}

Allen, Judith E. ^{[3
,4
,10
]}

机构：

[1] Univ Complutense Madrid, Dept Biochem & Mol Biol 1, E-28040 Madrid, Spain

[2] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid 28029, Spain

[3] Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3FL, Midlothian, Scotland

[4] Univ Edinburgh, Sch Clin Sci, Edinburgh EH9 3FL, Midlothian, Scotland

[5] Univ Manchester, Manchester Collaborat Ctr Inflammat Res, Fac Biol Med & Hlth, Manchester M13 9NT, Lancs, England

[6] Univ Autonoma Barcelona, Corp Sanitaria Univ Parc Tauli, Crit Care Ctr, Parc Tauli 1, Sabadell 08208, Spain

[7] Leibniz Ctr Med & Biosci, Res Ctr Borstel, Div Cellular Pneumol, D-23845 Borstel, Germany

[8] Univ Lubeck, Dept Anesthesiol & Intens Care, D-23538 Lubeck, Germany

[9] Penn State Univ, Coll Med, Pulm Immunol & Physiol Lab, Dept Pediat & Microbiol & Immunol, Hershey, PA 17033 USA

[10] Univ Manchester, Manchester Acad Hlth Sci Ctr, Wellcome Ctr Cell Matrix Res, Fac Biol Med & Hlth, Manchester M13 9PT, Lancs, England

[11] Karolinska Inst, Dept Med Solna, S-17176 Stockholm, Sweden

来源：

SCIENCE | 2017年 / 356卷 / 6342期

基金：

英国惠康基金; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

SURFACTANT PROTEIN-A; TISSUE-REPAIR; POLARIZATION; RESPONSES; FIBROSIS; IMMUNITY; ROLES; MICE;

D O I：

10.1126/science.aaj2067

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type 2-mediated macrophage activation. In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection, but resulted in fibrosis after peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.

引用

页码：1076 / 1080

页数：5

共 29 条

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