Astatine-211 imaging by a Compton camera for targeted radiotherapy

被引：18
作者：
Nagao, Yuto [1 ,2 ]
Yamaguchi, Mitsutaka [1 ]
Watanabe, Shigeki [1 ]
Ishioka, Noriko S. [1 ]
Kawachi, Naoki [1 ]
Watabe, Hiroshi [1 ,2 ,3 ]
机构：
[1] Natl Inst Quantum & Radiol Sci & Technol, Takasaki Adv Radiat Res Inst, 1233 Watanuki, Takasaki, Gunma 3701292, Japan
[2] Tohoku Univ, Grad Sch Biomed Engn, Aoba Ku, 6-6-12 Aoba, Sendai, Miyagi 9808579, Japan
[3] Tohoku Univ, Cyclotron & Radioisotope Ctr, Aoba Ku, 6-3 Aoba, Sendai, Miyagi 9808578, Japan
来源：
APPLIED RADIATION AND ISOTOPES | 2018年 / 139卷
关键词：
Astatine-211; Compton camera; Monte Carlo simulation; Targeted radiotherapy; NEUTRON-CAPTURE THERAPY; NUCLEAR-DATA SHEETS; PROMPT GAMMA-RAYS; AT-211; DOSIMETRY; SYSTEM;
D O I：
10.1016/j.apradiso.2018.05.022
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Astatine-211 is a promising radionuclide for targeted radiotherapy. It is required to image the distribution of targeted radiotherapeutic agents in a patient's body for optimization of treatment strategies. We proposed to image At-211 with high-energy photons to overcome some problems in conventional planar or single-photon emission computed tomography imaging. We performed an imaging experiment of a point-like At-211 source using a Compton camera, and demonstrated the capability of imaging At-211 with the high-energy photons for the first time.
引用
收藏
页码：238 / 243
页数：6
相关论文
共 34 条
[1]   Nuclear Data Sheets for A=211 [J].
Abriola, Daniel ;
Baglin, Coral ;
Demetriou, Vivian ;
Johnson, Timothy ;
McCutchan, Elizabeth ;
Mukherjee, Gopal ;
Singh, Sukhjeet ;
Sonzogni, Alejandro ;
Tuli, Jagdish .
NUCLEAR DATA SHEETS, 2013, 114 (6-7) :661-749
[2]   Development of a Compton camera for prompt-gamma medical imaging [J].
Aldawood, S. ;
Thirolf, P. G. ;
Miani, A. ;
Boehmer, M. ;
Dedes, G. ;
Gernhauser, R. ;
Lang, C. ;
Liprandi, S. ;
Maier, L. ;
Marinsek, T. ;
Mayerhofer, M. ;
Schaart, D. R. ;
Lozano, I. Valencia ;
Parodi, K. .
RADIATION PHYSICS AND CHEMISTRY, 2017, 140 :190-197
[3]   Development of a preclinical 211Rn/211At generator system for targeted alpha therapy research with 211At [J].
Crawford, Jason R. ;
Yang, Hua ;
Kunz, Peter ;
Wilbur, D. Scott ;
Schaffer, Paul ;
Ruth, Thomas J. .
NUCLEAR MEDICINE AND BIOLOGY, 2017, 48 :31-35
[4]   Compton camera study for high efficiency SPECT and benchmark with Anger system [J].
Fontana, M. ;
Dauvergne, D. ;
Letang, J. M. ;
Ley, J-L ;
Testa, E. .
PHYSICS IN MEDICINE AND BIOLOGY, 2017, 62 (23) :8794-8812
[5]  
GARG PK, 1990, CANCER RES, V50, P3514
[6]   Optimization of the Compton camera for measuring prompt gamma rays in boron neutron capture therapy [J].
Gong, Chun-hui ;
Tang, Xiao-bin ;
Shu, Di-yun ;
Yu, Hai-yan ;
Geng, Chang-ran .
APPLIED RADIATION AND ISOTOPES, 2017, 124 :62-67
[7]   Production of [211At]-Astatinated Radiopharmaceuticals and Applications in Targeted α-Particle Therapy [J].
Guerard, Francois ;
Gestin, Jean-Francois ;
Brechbiel, Martin W. .
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2013, 28 (01) :1-20
[8]   Prompt Gamma Rays Detected with a BGO Block Compton Camera Reveal Range Deviations of Therapeutic Proton Beams [J].
Hueso-Gonzalez F. ;
Pausch G. ;
Petzoldt J. ;
Romer K.E. ;
Enghardt W. .
1600, Institute of Electrical and Electronics Engineers Inc. (01) :76-86
[9]   Use of a LYSO-based Compton camera for prompt gamma range verification in proton therapy [J].
Jan, Meei-Ling ;
Hsiao, Ing-Tsung ;
Huang, Hsuan-Ming .
MEDICAL PHYSICS, 2017, 44 (12) :6261-6269
[10]   QUANTITATION OF AT-211 IN SMALL VOLUMES FOR EVALUATION OF TARGETED RADIOTHERAPY IN ANIMAL-MODELS [J].
JOHNSON, EL ;
TURKINGTON, TG ;
JASZCZAK, RJ ;
GILLAND, DR ;
VAIDYANATHAN, G ;
GREER, KL ;
COLEMAN, RE ;
ZALUTSKY, MR .
NUCLEAR MEDICINE AND BIOLOGY, 1995, 22 (01) :45-54
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