Photoadducts of metallic compounds with nucleic acids -: Role played by the photoelectron transfer process and by the TAP and HAT Ligands in the RuII complexes

被引：48
作者：
Blasius, R [1 ]
Moucheron, C [1 ]
Kirsch-De Mesmaeker, A [1 ]
机构：
[1] Free Univ Brussels, B-1050 Brussels, Belgium
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2004年 / 20期
关键词：
photoadducts; electron transfer; ruthenium(II) complexes; GMP; DNA;
D O I：
10.1002/ejic.200400489
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The properties that are characteristic of TAP (1,4,5,8-tetraazaphenanthrene) and HAT (1,4,5,8,9,12-hexaazatriphenylene) Ru-II complexes under illumination are highlighted and compared with those of other metallic complexes. In particular, the photo-oxidizing power of their (MLCT)-M-3 states leads to a quenching of luminescence accompanied by a photoreaction when they are in presence of nucleic acids. The proton-coupled photoinduced electron transfer with the guanine nucleobases produces metallic adducts on DNA guanine units. The mechanism of formation, structure, and possible applications of these photoadducts are discussed and compared with other DNA metallic adducts currently in the literature. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
引用
收藏
页码：3971 / 3979
页数：9
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