Multi-Omics Approaches in Immunological Research

被引：35
|
作者：
Chu, Xiaojing [1 ,2 ,3 ]
Zhang, Bowen [2 ,3 ]
Koeken, Valerie A. C. M. [2 ,3 ]
Gupta, Manoj Kumar [2 ,3 ]
Li, Yang [1 ,2 ,3 ,4 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands
[2] Joint venture Hannover Med Sch & Helmholtz Ctr In, Ctr Individualised Infect Med, Dept Computat Biol Individualised Med, Hannover, Germany
[3] Helmholtz Ctr Infect Res, Joint venture Hannover Med Sch, Ctr Expt & Clin Infect Res, TWINCORE, Hannover, Germany
[4] Radboud Univ Nijmegen Med Ctr, Radboud Ctr Infect Dis, Dept Internal Med, Nijmegen, Netherlands
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词：
multi-omics; systems immunology; integrative analysis; immune-related diseases; immune variation; NEURO-IMMUNE INTERACTIONS; NEXT-GENERATION; INTEGRATIVE ANALYSIS; CYTOKINE PRODUCTION; GENETIC INFLUENCES; DISEASE; ASSOCIATION; CELLS; METHYLATION; CHROMATIN;
D O I：
10.3389/fimmu.2021.668045
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immune system plays a vital role in health and disease, and is regulated through a complex interactive network of many different immune cells and mediators. To understand the complexity of the immune system, we propose to apply a multi-omics approach in immunological research. This review provides a complete overview of available methodological approaches for the different omics data layers relevant for immunological research, including genetics, epigenetics, transcriptomics, proteomics, metabolomics, and cellomics. Thereafter, we describe the various methods for data analysis as well as how to integrate different layers of omics data. Finally, we discuss the possible applications of multi-omics studies and opportunities they provide for understanding the complex regulatory networks as well as immune variation in various immune-related diseases.
引用
收藏
页数：16
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