The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives

被引:58
作者
Inanc, Tugrul [1 ]
Kaya, Mehmet Gungor [1 ]
Yarlioglues, Mikail [1 ]
Ardic, Idris [1 ]
Ozdogru, Ibrahim [1 ]
Dogan, Ali [1 ]
Kalay, Nihat [1 ]
Gunturk, Ertugrul [1 ]
Gunebakmaz, Ozgur [1 ]
Gul, Ibrahim [1 ]
Topsakal, Ramazan [1 ]
机构
[1] Erciyes Univ, Sch Med, Dept Cardiol, Kayseri, Turkey
关键词
AMBULATORY BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; RISK-FACTOR; DISEASE; STROKE; COUNT; ASSOCIATION; INDEXES; EDTA;
D O I
10.3109/08037050903516284
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objectives. Increased platelet activation plays an important role in the development of atherosclerosis. Mean platelet volume (MPV) is a determinant of platelet activation. In our study, we aimed to determine whether MPV levels are elevated in non-dipper patients compared with dippers and healthy controls. In addition, we tried to find out if MPV levels are correlated with blood pressure measurements in hypertensive patients. Methods. This cross-sectional study included 56 hypertensive patients; 27 age- and sex-matched healthy volunteers were enrolled to study as a control subjects. Ambulatory blood pressure monitoring was performed for all patients. Hypertensive patients were divided into two groups: 28 dipper patients (10 male, mean age 51 +/- 8 years) and 28 non-dipper patients (11 male, mean age 53 +/- 10 years). MPV was measured in a blood sample collected in EDTA tubes and was also used for whole blood counts in all patients. Results. In non-dipper patients, 24-h systolic blood pressure (141.5 +/- 10.21 vs 132.3 +/- 7.7 mmHg, p < 0.001), 24-h diastolic blood pressure (88.2 +/- 8.5 vs 81.0 +/- 8.2 mmHg, p < 0.01) and 24-h average blood pressure (105.7 +/- 8.5 vs 97.7 +/- 7.4 mmHg, p < 0.001) are significantly higher than dippers. Whereas daytime measurements were similar between dippers and non-dippers, there was a significant difference between each group during night-time measurements (night-time systolic 137.1 +/- 11.0 vs 120.2 +/- 8.0 mmHg, p < 0.001; night-time diastolic 85.3 +/- 8.0 vs 72.8 +/- 7.9 mmHg, p < 0.001). Non-dipper patients (9.61 +/- 0.42 fl) demonstrated higher levels of MPV compared with dippers (9.24 +/- 0.35 fl) and normotensives (8.87 +/- 0.33 fl) (p < 0.001 and p < 0.001, respectively). There was significant correlation between MPV and ambulatory diastolic and systolic blood pressure in non-dipper hypertensives. Conclusion. Our results suggest that MPV, a determinant of platelet activation, has a positively correlation with blood pressure and elevated in non-dipper compared with dippers and controls. Increased platelet activation could contribute to increase the atherosclerotic risk in non-dipper patients compared with dippers.
引用
收藏
页码:81 / 85
页数:5
相关论文
共 28 条
[1]   Circadian Pattern of Ambulatory Blood Pressure in Untreated Hypertensive Patients with and without Metabolic Syndrome [J].
Ayala, Diana E. ;
Hermida, Ramon C. ;
Chayan, Luisa ;
Mojon, Artemio ;
Fontao, Maria J. ;
Fernandez, Jose R. .
CHRONOBIOLOGY INTERNATIONAL, 2009, 26 (06) :1189-1205
[2]   Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease [J].
Bath, P ;
Algert, C ;
Chapman, N ;
Neal, B .
STROKE, 2004, 35 (03) :622-626
[3]   Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis [J].
Brown, AS ;
Hong, Y ;
deBelder, A ;
Beacon, H ;
Beeso, J ;
Sherwood, R ;
Edmonds, M ;
Martin, JF ;
Erusalimsky, JD .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (04) :802-807
[4]   Widespread coronary inflammation in unstable angina [J].
Buffon, A ;
Biasucci, LM ;
Liuzzo, G ;
D'Onofrio, G ;
Crea, F ;
Maseri, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (01) :5-12
[5]   The effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume [J].
Ceyhan, Temel ;
Beyan, Cengiz ;
Baser, Iskender ;
Kaptan, Kursat ;
Gungor, Sadettin ;
Ifran, Ahmet .
ANNALS OF HEMATOLOGY, 2006, 85 (05) :320-322
[6]  
CHASEN C, 1998, BLOOD PRESS MONIT, V127, P721
[7]   Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [J].
Chobanian, AV ;
Bakris, GL ;
Black, HR ;
Cushman, WC ;
Green, LA ;
Izzo, JL ;
Jones, DW ;
Materson, BJ ;
Oparil, S ;
Wright, JT ;
Roccella, EJ .
HYPERTENSION, 2003, 42 (06) :1206-1252
[8]   The mean platelet volume in patients with essential and white coat hypertension [J].
Coban, E ;
Yazicioglu, G ;
Avci, AB ;
Akcit, F .
PLATELETS, 2005, 16 (07) :435-438
[9]   Meta-analysis of the morning excess of acute myocardial infarction and sudden cardiac death [J].
Cohen, MC ;
Rohtla, KM ;
Lavery, CE ;
Muller, JE ;
Mittleman, MA .
AMERICAN JOURNAL OF CARDIOLOGY, 1997, 79 (11) :1512-+
[10]   Mean platelet volume measurement, EDTA or citrate? [J].
Dastjerd, Mansour Siavash ;
Emami, Tajolmolouk ;
Najafian, Alireza ;
Amini, Masoud .
HEMATOLOGY, 2006, 11 (5-6) :317-319