First total synthesis of the marine alkaloids purpurone and ningalin C

被引：42

作者：

Peschko, C ^{[1
]}

Steglich, W ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 49期

关键词：

purpurone; ningalins; marine natural products; ACL inhibitors; pyrrole alkaloids;

D O I：

10.1016/S0040-4039(00)01614-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Purpurone is obtained from 3-(3,4-dimethoxyphenyl)pyruvic acid, 2-(4-methoxyphenyl)ethylamine and 2',2',2'-trichloroethyl 2-bromo-2-(3,4-dimethoxyphenyl)acetate in seven steps with an overall yield of 11%. Ningalin C is synthesized from 1-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-bis-(3,4-dimethoxyphenyl)-1H-pyrrole and methyl 2-diazo-2-(3,4-dimethoxyphenyl)acetate in five steps with a total yield of 19%. (C) 2000 Published by Elsevier Science Ltd.

引用

收藏

页码：9477 / 9481

页数：5

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