Melt electrospinning of poly(ε-caprolactone) scaffolds: Phenomenological observations associated with collection and direct writing

被引:126
作者
Brown, Toby D. [1 ]
Edin, Fredrik [1 ]
Detta, Nicola [1 ]
Skelton, Anthony D. [1 ]
Hutmacher, Dietmar W. [1 ,2 ,3 ]
Dalton, Paul D. [1 ,4 ]
机构
[1] Queensland Univ Technol, Inst Hlth & Biomed Innovat, 60 Musk Ave, Kelvin Grove 4059, Australia
[2] Tech Univ Munich, Inst Adv Study, D-85748 Garching, Germany
[3] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA
[4] Univ Wurzburg, Dept Funct Mat Med & Dent, D-97070 Wurzburg, Germany
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2014年 / 45卷
关键词
Electrospinning; Fibers; Tissue engineering; 3D printing; Additive manufacturing; Electrohydrodynamic writing; NANOFIBERS; FABRICATION; MORPHOLOGY; DIAMETER;
D O I
10.1016/j.msec.2014.07.034
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Melt electrospinning and its additive manufacturing analogue, melt electrospinning writing (MEW), are two processes which can produce porous materials for applications where solvent toxicity and accumulation in solution electrospinning are problematic. This study explores the melt electrospinning of poly(epsilon-caprolactone) (PCL) scaffolds, specifically for applications in tissue engineering. The research described here aims to inform researchers interested in melt electrospinning about technical aspects of the process. This includes rapid fiber characterization using glass microscope slides, allowing influential processing parameters on fiber morphology to be assessed, as well as observed fiber collection phenomena on different collector substrates. The distribution and alignment of melt electrospun PCL fibers can be controlled to a certain degree using patterned collectors to create large numbers of scaffolds with shaped macroporous architectures. However, the buildup of residual charge in the collected fibers limits the achievable thickness of the porous template through such scaffolds. One challenge identified for MEW is the ability to control charge buildup so that fibers can be placed accurately in close proximity, and in many centimeter heights. The scale and size of scaffolds produced using MEW, however, indicate that this emerging process will fill a technological niche in biofabricadon. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:698 / 708
页数:11
相关论文
共 45 条
[1]   On the way to clean and safe electrospinning-green electrospinning: emulsion and suspension electrospinning [J].
Agarwal, Seema ;
Greiner, Andreas .
POLYMERS FOR ADVANCED TECHNOLOGIES, 2011, 22 (03) :372-378
[2]   Electrospinning: A fascinating fiber fabrication technique [J].
Bhardwaj, Nandana ;
Kundu, Subhas C. .
BIOTECHNOLOGY ADVANCES, 2010, 28 (03) :325-347
[3]   Design and Fabrication of Tubular Scaffolds via Direct Writing in a Melt Electrospinning Mode [J].
Brown, Toby D. ;
Slotosch, Anna ;
Thibaudeau, Laure ;
Taubenberger, Anna ;
Loessner, Daniela ;
Vaquette, Cedryck ;
Dalton, Paul D. ;
Hutmacher, Dietmar W. .
BIOINTERPHASES, 2012, 7 (1-4) :1-16
[4]   Direct Writing By Way of Melt Electrospinning [J].
Brown, Toby D. ;
Dalton, Paul D. ;
Hutmacher, Dietmar W. .
ADVANCED MATERIALS, 2011, 23 (47) :5651-+
[5]   Characterization of gelatin nanofibers electrospun using ethanol/formic acid/water as a solvent [J].
Chen, Hsin-Chieh ;
Jao, Win-Chun ;
Yang, Ming-Chien .
POLYMERS FOR ADVANCED TECHNOLOGIES, 2009, 20 (02) :98-103
[6]   Design, fabrication and characterization of PCL electrospun scaffolds-a review [J].
Cipitria, A. ;
Skelton, A. ;
Dargaville, T. R. ;
Dalton, P. D. ;
Hutmacher, D. W. .
JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (26) :9419-9453
[7]  
Cui W., 2011, Comprehensive Biomaterials, P445, DOI [10.1088/1468-6996/11/1/014108, DOI 10.1088/1468-6996/11/1/014108]
[8]  
Dahlin RL, 2011, TISSUE ENG PART B-RE, V17, P349, DOI [10.1089/ten.teb.2011.0238, 10.1089/ten.TEB.2011.0238]
[9]  
Dalton Paul D., 2006, Biotechnology Journal, V1, P998, DOI 10.1002/biot.200600064
[10]   Electrospinning of polymer melts:: Phenomenological observations [J].
Dalton, Paul D. ;
Grafahrend, Dirk ;
Klinkhammer, Kristina ;
Klee, Doris ;
Moeller, Martin .
POLYMER, 2007, 48 (23) :6823-6833