Direct determination of colonic nitric oxide level - A sensitive marker of disease activity in ulcerative colitis

被引:36
作者
Rachmilewitz, D [1 ]
Eliakim, R [1 ]
Ackerman, Z [1 ]
Karmeli, F [1 ]
机构
[1] Hebrew Univ Jerusalem, Hadassah Univ Hosp, Hadassah Med Sch, Dept Med, IL-91240 Jerusalem, Israel
关键词
D O I
10.1016/S0002-9270(98)00009-4
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective: In active ulcerative colitis, colonic nitric oxide (NO) generation is enhanced and probably has an important role in its pathogenesis, We tested the reliability of an NO electrode in monitoring colonic NO levels in ulcerative colitis patients and control subjects and its possible usage as a marker of disease activity, Methods: Colonic NO level was determined by the NO detection system model NO-501 (InterMedical, Nagoya, Japan), The working electrode was inserted into a 7-mm diameter polyvinyl tube and introduced at a distance 6 cm from the anus, In each subject sigmoidoscopy was performed and mucosal biopsies were obtained. NO synthase (NOS) activity was determined by monitoring the conversion of H-3-arginine to citrulline. Results: Colonic NO level is significantly increased in patients with active ulcerative or Crohn's colitis-more than 2-fold higher than in control subjects. There was good correlation between colonic NO level and NOS activity and the clinical and endoscopic indices of disease activity, Conclusion: Direct determination of colonic NO level is convenient, and reliable, and may help to monitor disease activity in ulcerative colitis. (C) 1998 by Am. Coil. of Gastroenterology.
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页码:409 / 412
页数:4
相关论文
共 16 条
[1]   NITRIC-OXIDE SYNTHASE FROM CEREBELLUM CATALYZES THE FORMATION OF EQUIMOLAR QUANTITIES OF NITRIC-OXIDE AND CITRULLINE FROM L-ARGININE [J].
BUSH, PA ;
GONZALEZ, NE ;
GRISCAVAGE, JM ;
IGNARRO, LJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 185 (03) :960-966
[2]  
ELIAKIM R, 1992, GASTROENTEROL INT, V5, P48
[3]   PRACTICAL NITRIC-OXIDE MEASUREMENT EMPLOYING A NITRIC OXIDE-SELECTIVE ELECTRODE [J].
ICHIMORI, K ;
ISHIDA, H ;
FUKAHORI, M ;
NAKAZAWA, H ;
MURAKAMI, E .
REVIEW OF SCIENTIFIC INSTRUMENTS, 1994, 65 (08) :2714-2718
[4]   GREATLY INCREASED LUMINAL NITRIC-OXIDE IN ULCERATIVE-COLITIS [J].
LUNDBERG, JON ;
HELLSTROM, PM ;
LUNDBERG, JM ;
ALVING, K .
LANCET, 1994, 344 (8938) :1673-1674
[5]   INCREASED NITRIC-OXIDE SYNTHESIS IN ULCERATIVE-COLITIS [J].
MIDDLETON, SJ ;
SHORTHOUSE, M ;
HUNTER, JO .
LANCET, 1993, 341 (8843) :465-466
[6]   PRODUCTION OF NITRIC-OXIDE IN ANAPHYLAXIS IN RABBITS [J].
MITSUHATA, H ;
SAITOH, J ;
TAKEUCHI, H ;
HASOME, N ;
HORIGUCHI, Y ;
SHIMIZU, R .
SHOCK, 1994, 2 (05) :381-384
[7]   ENDOTOXIN-INDUCED NONENDOTHELIAL NITRIC-OXIDE ACTIVATES THE CA2+-ACTIVATED K+ CHANNEL IN CULTURED VASCULAR SMOOTH-MUSCLE CELLS [J].
MIYOSHI, H ;
NAKAYA, Y .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1994, 26 (11) :1487-1495
[8]   INDUCTION OF NITRIC-OXIDE SYNTHASE IN COLONIC SMOOTH-MUSCLE FROM PATIENTS WITH TOXIC MEGACOLON [J].
MOURELLE, M ;
CASELLAS, F ;
GUARNER, F ;
SALAS, A ;
RIVEROSMORENO, V ;
MONCADA, S ;
MALAGELADA, JR .
GASTROENTEROLOGY, 1995, 109 (05) :1497-1502
[9]  
MOURELLE M, 1995, INFLAMM BOWEL DIS, P106
[10]   SULFHYDRYL BLOCKER-INDUCED RAT COLONIC INFLAMMATION IS AMELIORATED BY INHIBITION OF NITRIC-OXIDE SYNTHASE [J].
RACHMILEWITZ, D ;
KARMELI, F ;
OKON, E .
GASTROENTEROLOGY, 1995, 109 (01) :98-106