Pharmacology of Na+/Ca2+ exchanger

被引:0
作者
Kimura, J
Watanabe, Y
Li, LB
Watano, T
机构
[1] Fukushima Med Univ, Sch Med, Dept Pharmacol, Fukushima 9601295, Japan
[2] Fukushima Med Univ, Sch Nursing, Dept Ecol & Clin Therapeut, Fukushima 9601295, Japan
来源
CELLULAR AND MOLECULAR PHYSIOLOGY OF SODIUM-CALCIUM EXCHANGE | 2002年 / 976卷
关键词
Na+/Ca2+ exchanger; NCX pharmacology; KBR7943; antiarrhythmic agents; amiodarone;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
KB-R7943 inhibits the Na+/Ca2+ exchanger in an independent manner or in a manner dependent on the direction of the current. This effect may be due to the experimental protocols hawed on the competition between the drug and external substrate ions. Some antiarrhythmic drugs inhibit NCX. A new column of NCX was added in Sicilian Gambit.
引用
收藏
页码:513 / 519
页数:7
相关论文
共 21 条
[1]   A Ca2+-dependent tryptic cleavage site and a protein kinase A phosphorylation site are present in the Ca2+ regulatory domain of scallop muscle Na+-Ca2+ exchanger [J].
Chen, MG ;
Zhang, ZM ;
Tawiah-Boateng, MA ;
Hardwicke, PMD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (30) :22961-22968
[2]  
DOERING AE, 1993, J PHYSL, V476, P443
[3]   Inhibition of Na+/Ca2+ exchange by KB-R7943:: transport mode selectivity and antiarrhythmic consequences [J].
Elias, CL ;
Lukas, A ;
Shurraw, S ;
Scott, J ;
Omelchenko, A ;
Gross, GJ ;
Hnatowich, M ;
Hryshko, LV .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (03) :H1334-H1345
[4]   REGULATION AND DEREGULATION OF CARDIAC NA+-CA2+ EXCHANGE IN GIANT EXCISED SARCOLEMMAL MEMBRANE PATCHES [J].
HILGEMANN, DW .
NATURE, 1990, 344 (6263) :242-245
[5]  
Hotta Y, 2002, JPN J PHARMACOL, V88, p257P
[6]   Structural domains influencing sensitivity to isothiourea derivative inhibitor KB-R7943 in cardiac Na+/Ca2+ exchanger [J].
Iwamoto, T ;
Kita, S ;
Uehara, A ;
Inoue, Y ;
Taniguchi, Y ;
Imanaga, I ;
Shigekawa, M .
MOLECULAR PHARMACOLOGY, 2001, 59 (03) :524-531
[7]   Direction-independent block of bi-directional Na+/Ca2+ exchange current by KB-R7943 in guinea-pig cardiac myocytes [J].
Kimura, J ;
Watano, T ;
Kawahara, M ;
Sakai, E ;
Yatabe, J .
BRITISH JOURNAL OF PHARMACOLOGY, 1999, 128 (05) :969-974
[8]   Cellular electropharmacology of amiodarone [J].
Kodama, I ;
Kamiya, K ;
Toyama, J .
CARDIOVASCULAR RESEARCH, 1997, 35 (01) :13-29
[9]  
Matsuda T, 2001, J PHARMACOL EXP THER, V298, P249
[10]  
MATUSOKA S, 1994, J PHYSL, V476, P443